Contact information
Michael Browning
Clinical Post Doctoral Researcher
My current research focuses on the role of learning abnormalities in the aetiology of anxiety.
Anxiety disorders are among the most common of the psychiatric illness. While there has been significant recent advances in understanding the neural systems involved in producing symptoms of anxiety in response to stressful circumstances, it is less clear why, when exposed to the same stress, some people will become anxious while others will not. The overall goal of my research is to better understand the mechanisms which lead to this vulnerability -- the importance of this research is that an understanding of these underlying mechanisms is an essential first step in the development of novel, evidence based treatments for anxiety.
My work uses computational models of learning, developed to explain how people learn about rewards in their environment, and asks whether similar processes can explain the difficulties in learning seen in people with anxiety.
Key publications
-
Effects of 7 days of treatment with the cannabinoid type 1 receptor antagonist, rimonabant, on emotional processing.
Journal article
Horder J. et al, (2012), J Psychopharmacol, 26, 125 - 132
-
Effects of low dose tryptophan depletion on emotional processing in dieters.
Journal article
Pringle A. et al, (2012), Eat Behav, 13, 154 - 157
-
Social inference and social anxiety: evidence of a fear-congruent self-referential learning bias.
Journal article
Button KS. et al, (2012), J Behav Ther Exp Psychiatry, 43, 1082 - 1087
-
Expectancy and surprise predict neural and behavioral measures of attention to threatening stimuli.
Journal article
Browning M. and Harmer CJ., (2012), Neuroimage, 59, 1942 - 1948
-
The use of cognitive bias modification and imagery in the understanding and treatment of depression.
Journal article
Browning M. et al, (2013), Curr Top Behav Neurosci, 14, 243 - 260
Recent publications
-
Missing a trick? Bupropion for the pharmacological treatment of depression in the UK.
Journal article
Browning M. and Cowen PJ., (2025), Br J Psychiatry, 1 - 3
-
Effect of lithium on circadian activity level and flexibility in patients with bipolar disorder: results from the Oxford Lithium Trial.
Journal article
Xu N. et al, (2025), EBioMedicine, 115
-
Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression: a pragmatic, open-label, parallel-group, randomised controlled superiority trial in the UK.
Journal article
Cleare AJ. et al, (2025), Lancet Psychiatry, 12, 276 - 288
-
Prefrontal cortex stimulation normalizes deficient adaptive learning from outcome contingencies in low mood.
Journal article
Sarrazin V. et al, (2024), Transl Psychiatry, 14
-
Direct serotonin release in humans shapes aversive learning and inhibition.
Journal article
Colwell MJ. et al, (2024), Nat Commun, 15