Frances Ashcroft

• Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

  Journal article

  Ashcroft FM. et al, (2017), Cell Metab, 26, 17 - 23

• Neonatal Diabetes and the KATP Channel: From Mutation to Therapy.

  Journal article

  Ashcroft FM. et al, (2017), Trends Endocrinol Metab, 28, 377 - 387

• Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes.

  Journal article

  Dahan T. et al, (2017), Diabetes, 66, 426 - 436

• Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.

  Journal article

  Brereton MF. et al, (2016), Nat Commun, 7

• Correction to 'Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels'.

  Journal article

  Proks P. et al, (2016), Philos Trans R Soc Lond B Biol Sci, 371

• β-Cell dysfunction in diabetes: a crisis of identity?

  Journal article

  Brereton MF. et al, (2016), Diabetes Obes Metab, 18 Suppl 1, 102 - 109

• Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels.

  Journal article

  Proks P. et al, (2016), Philos Trans R Soc Lond B Biol Sci, 371

• Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk.

  Journal article

  Vedovato N. et al, (2016), Diabetologia, 59, 1430 - 1436

• Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes.

  Journal article

  Babiker T. et al, (2016), Diabetologia, 59, 1162 - 1166

• The Nucleotide-Binding Sites of SUR1: A Mechanistic Model.

  Journal article

  Vedovato N. et al, (2015), Biophys J, 109, 2452 - 2460

• Q&A: Insulin secretion and type 2 diabetes: Why do β-cells fail?

  Journal article

  Cantley J. and Ashcroft FM., (2015), BMC Biology, 13

• The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation.

  Journal article

  O'Connell SM. et al, (2015), Clin Case Rep, 3, 884 - 887

• Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

  Journal article

  Cantley J. and Ashcroft FM., (2015), BMC Biol, 13

• FTO influences adipogenesis by regulating mitotic clonal expansion.

  Journal article

  Merkestein M. et al, (2015), Nat Commun, 6

• Pharmacological inhibition of FTO.

  Journal article

  McMurray F. et al, (2015), PLoS One, 10

• Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents.

  Journal article

  Lahmann C. et al, (2015), PLoS One, 10

• Fetal macrosomia and neonatal hyperinsulinemic hypoglycemia associated with transplacental transfer of sulfonylurea in a mother with KCNJ11-related neonatal diabetes.

  Journal article

  Myngheer N. et al, (2014), Diabetes Care, 37, 3333 - 3335

• Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study.

  Journal article

  Proks P. et al, (2014), J Gen Physiol, 144, 469 - 486

• Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

  Journal article

  Zhang Q. et al, (2014), J Physiol, 592, 4677 - 4696

• Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.

  Journal article

  Brereton MF. et al, (2014), Nat Commun, 5

• A mutation causing increased KATP channel activity leads to reduced anxiety in mice.

  Journal article

  Lahmann C. et al, (2014), Physiol Behav, 129, 79 - 84

• Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.

  Journal article

  Tornovsky-Babeay S. et al, (2014), Cell Metab, 19, 109 - 121

• Changes in gene expression associated with FTO overexpression in mice.

  Journal article

  Merkestein M. et al, (2014), PLoS One, 9

• Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.

  Journal article

  Zhang Q. et al, (2013), Cell Metab, 18, 871 - 882

• K(ATP) channels and islet hormone secretion: new insights and controversies.

  Journal article

  Ashcroft FM. and Rorsman P., (2013), Nat Rev Endocrinol, 9, 660 - 669

• K<inf>ATP</inf> channels and islet hormone secretion: New insights and controversies

  Journal article

  Ashcroft FM. and Rorsman P., (2013), Nature Reviews Endocrinology, 9, 660 - 669

• Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.

  Journal article

  Proks P. et al, (2013), Diabetes, 62, 3909 - 3919

• A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.

  Journal article

  Shimomura K. et al, (2013), Diabetes, 62, 3797 - 3806

• Insulin prevents counter-regulatory glucagon secretion by stimulation of somatostatin release

  Conference paper

  Rorsman P. et al, (2013), DIABETOLOGIA, 56, S243 - S244

• Switching to sulphonylureas in children with iDEND syndrome caused by KCNJ11 mutations results in improved cerebellar perfusion.

  Journal article

  Fendler W. et al, (2013), Diabetes Care, 36, 2311 - 2316

• Role for the obesity-related FTO gene in the cellular sensing of amino acids.

  Journal article

  Gulati P. et al, (2013), Proc Natl Acad Sci U S A, 110, 2557 - 2562

• Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles

  Journal article

  Fotinou C. et al, (2013), FEBS Journal, 280, 1051 - 1063

• Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.

  Journal article

  Fotinou C. et al, (2013), FEBS J, 280, 1051 - 1063

• Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

  Journal article

  McMurray F. et al, (2013), PLoS Genet, 9

• Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.

  Journal article

  Loh NY. et al, (2013), PLoS One, 8

• Mouse models of β-cell K channel dysfunction

  Journal article

  Brereton MF. and Ashcroft FM., (2013), Drug Discovery Today: Disease Models

• Gain-of-function mutations in the K(ATP) channel (KCNJ11) impair coordinated hand-eye tracking.

  Journal article

  McTaggart JS. et al, (2013), PLoS One, 8

• A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.

  Journal article

  de Wet H. et al, (2012), J Physiol, 590, 5025 - 5036

• A universally conserved residue in the SUR1 subunit of the K <inf>ATP</inf> channel is essential for translating nucleotide binding at SUR1 into channel opening

  Journal article

  de Wet H. et al, (2012), Journal of Physiology, 590, 5025 - 5036

• Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities.

  Journal article

  Clark R. et al, (2012), Diabetologia, 55, 1195 - 1204

• Diabetes mellitus and the β cell: the last ten years.

  Journal article

  Ashcroft FM. and Rorsman P., (2012), Cell, 148, 1160 - 1171

• Mice expressing a human K ATP channel mutation have altered channel ATP sensitivity but no cardiac abnormalities

  Journal article

  Clark R. et al, (2012), Diabetologia, 1 - 10

• A high-throughput assay for modulators of NNT activity in permeabilized yeast cells.

  Journal article

  Meadows NA. et al, (2011), J Biomol Screen, 16, 734 - 743

• A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated.

  Journal article

  Männikkö R. et al, (2011), J Physiol, 589, 3071 - 3083

• Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes.

  Journal article

  Männikkö R. et al, (2011), Diabetes, 60, 1813 - 1822

• Control of pancreatic β cell regeneration by glucose metabolism.

  Journal article

  Porat S. et al, (2011), Cell Metab, 13, 440 - 449

• Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca(2+) Channels from Secretory Granules.

  Journal article

  Hoppa MB. et al, (2011), Cell Metab, 13

• FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting.

  Journal article

  McTaggart JS. et al, (2011), PLoS One, 6

• Overexpression of Fto leads to increased food intake and results in obesity.

  Journal article

  Church C. et al, (2010), Nat Genet, 42, 1086 - 1092

• A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse.

  Journal article

  Hugill A. et al, (2010), Diabetologia, 53, 2352 - 2356

• Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.

  Journal article

  Proks P. et al, (2010), J Gen Physiol, 136, 389 - 405

• The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.

  Journal article

  McTaggart JS. et al, (2010), J Physiol, 588, 3201 - 3209

• Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin.

  Journal article

  Clark RH. et al, (2010), Science, 329, 458 - 461

• The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids.

  Journal article

  de Wet H. et al, (2010), FEBS J, 277, 2654 - 2662

• The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids

  Journal article

  De Wet H. et al, (2010), FEBS Journal, 277, 2654 - 2662

• Asymmetric switching in a homodimeric ABC transporter: a simulation study.

  Journal article

  Aittoniemi J. et al, (2010), PLoS Comput Biol, 6

• Interaction between mutations in the slide helix of Kir6.2 associated with neonatal diabetes and neurological symptoms.

  Journal article

  Männikkö R. et al, (2010), Hum Mol Genet, 19, 963 - 972

• New uses for old drugs: neonatal diabetes and sulphonylureas.

  Journal article

  Ashcroft FM., (2010), Cell Metab, 11, 179 - 181

• CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.

  Journal article

  Reed AA. et al, (2010), Am J Physiol Renal Physiol, 298, F365 - F380

• The first clinical case of a mutation at residue K185 of Kir6.2 (KCNJ11): a major ATP-binding residue.

  Journal article

  Shimomura K. et al, (2010), Diabet Med, 27, 225 - 229

• Investigation of Protonation Effects on ATP Binding in ABC Transporters

  Journal article

  Aittoniemi J. et al, (2010), BIOPHYSICAL JOURNAL, 98, 759A - 759A

• Investigating the PIP2 Binding Site in Kir Channels Via Multi-Scale Biomolecular Simulations

  Journal article

  Stansfeld PJ. et al, (2010), BIOPHYSICAL JOURNAL, 98, 698A - 698A

• Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

  Journal article

  Hoppa MB. et al, (2009), Cell Metab, 10, 455 - 465

• PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations.

  Journal article

  Stansfeld PJ. et al, (2009), Biochemistry, 48, 10926 - 10933

• A dominant mutation in the obesity susceptibility gene FTO results in reduced fat mass with enhanced lipid and carbohydrate metabolism

  Conference paper

  Church CD. et al, (2009), DIABETOLOGIA, 52, S90 - S90

• A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

  Journal article

  Church C. et al, (2009), PLoS Genet, 5

• An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1.

  Journal article

  Craig TJ. et al, (2009), J Clin Endocrinol Metab, 94, 2551 - 2557

• Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism.

  Journal article

  Shimomura K. et al, (2009), EMBO Mol Med, 1, 166 - 177

• A cytosolic factor that inhibits KATP channels expressed in Xenopus oocytes by impairing Mg-nucleotide activation by SUR1.

  Journal article

  Tammaro P. and Ashcroft FM., (2009), J Physiol, 587, 1649 - 1656

• Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.

  Journal article

  Aittoniemi J. et al, (2009), Philos Trans R Soc Lond B Biol Sci, 364, 257 - 267

• Modeling K(ATP) channel gating and its regulation.

  Journal article

  Proks P. and Ashcroft FM., (2009), Prog Biophys Mol Biol, 99, 7 - 19

• Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

  Journal article

  Girard CA. et al, (2009), J Clin Invest, 119, 80 - 90

• ATP-SENSITIVE POTASSIUM CHANNELS AND DIABETES: FROM MOLECULE TO MALADY

  Journal article

  Ashcroft FM., (2009), JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 8 - 8

• ATP-sensitive potassium channels in health and disease

  Chapter

  Proks P. and Ashcroft FM., (2008), Pancreatic Beta Cell in Health and Disease, 431 - 450

• PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.

  Journal article

  Zehetner J. et al, (2008), Genes Dev, 22, 3135 - 3146

• Permanent neonatal diabetes caused by an in-frame deletion in the N-terminus of Kir6.2

  Journal article

  Craig TJ. et al, (2008), DIABETOLOGIA, 51, S105 - S105

• A mouse model of neonatal diabetes caused by the K-ATP channel mutation Kir6.2-V59M

  Conference paper

  Girard CA. et al, (2008), DIABETOLOGIA, 51, S54 - S54

• Coincidence of a novel KCNJ11 missense variant R365H with a paternally inherited 6q24 duplication in a patient with transient neonatal diabetes.

  Journal article

  Staník J. et al, (2008), Diabetes Care, 31, 1736 - 1737

• Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.

  Journal article

  Goldsworthy M. et al, (2008), Diabetes, 57, 2234 - 2244

• Glucose regulates the effects of leptin on hypothalamic POMC neurons.

  Journal article

  Ma X. et al, (2008), Proc Natl Acad Sci U S A, 105, 9811 - 9816

• How ATP inhibits the open K(ATP) channel.

  Journal article

  Craig TJ. et al, (2008), J Gen Physiol, 132, 131 - 144

• A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.

  Journal article

  de Wet H. et al, (2008), EMBO Rep, 9, 648 - 654

• Variable phenotypic spectrum of diabetes mellitus in a family carrying a novel KCNJ11 gene mutation.

  Journal article

  D'Amato E. et al, (2008), Diabet Med, 25, 651 - 656

• A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complications.

  Journal article

  Tammaro P. et al, (2008), Diabetologia, 51, 802 - 810

• Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.

  Journal article

  Tricarico D. et al, (2008), Neuromuscul Disord, 18, 74 - 80

• Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy.

  Journal article

  Shield JP. et al, (2008), Diabetes, 57, 255 - 258

• The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

  Journal article

  Gerken T. et al, (2007), Science, 318, 1469 - 1472

• Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.

  Journal article

  de Wet H. et al, (2007), Proc Natl Acad Sci U S A, 104, 18988 - 18992

• A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.

  Journal article

  Tammaro P. and Ashcroft FM., (2007), J Physiol, 584, 743 - 753

• Functional analysis of two Kir6.2 (KCNJ11) mutations, K170T and E322K, causing neonatal diabetes.

  Journal article

  Tarasov AI. et al, (2007), Diabetes Obes Metab, 9 Suppl 2, 46 - 55

• Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11.

  Journal article

  Mlynarski W. et al, (2007), Nat Clin Pract Neurol, 3, 640 - 645

• The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady.

  Journal article

  Ashcroft FM., (2007), Am J Physiol Endocrinol Metab, 293, E880 - E889

• Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.

  Journal article

  Haider S. et al, (2007), EMBO J, 26, 3749 - 3759

• Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome.

  Journal article

  Proks P. et al, (2007), Hum Mol Genet, 16, 2011 - 2019

• Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects.

  Journal article

  Ellard S. et al, (2007), Am J Hum Genet, 81, 375 - 382

• Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.

  Journal article

  Ma X. et al, (2007), J Neurosci, 27, 7125 - 7129

• Studies of the ATPase activity of the ABC protein SUR1.

  Journal article

  de Wet H. et al, (2007), FEBS J, 274, 3532 - 3544

• Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

  Journal article

  Könner AC. et al, (2007), Cell Metab, 5, 438 - 449

• PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.

  Journal article

  Medina-Gomez G. et al, (2007), PLoS Genet, 3

• R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.

  Journal article

  Zhang Q. et al, (2007), Nat Cell Biol, 9, 453 - 460

• Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.

  Journal article

  Haider S. et al, (2007), Biochemistry, 46, 3643 - 3652

• Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin.

  Journal article

  Ma X. et al, (2007), J Neurosci, 27, 1529 - 1533

• The open state of KirBac3.1 observed by cryo-electron microscopy

  Conference paper

  Zadek B. et al, (2007), BIOPHYSICAL JOURNAL, 27A - 27A

• Keeping the heart going: a new role for KATP channels.

  Journal article

  Tammaro P. and Ashcroft FM., (2006), J Physiol, 577

• Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.

  Journal article

  Girard CA. et al, (2006), Pflugers Arch, 453, 323 - 332

• Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress.

  Journal article

  Freeman H. et al, (2006), Biochem Soc Trans, 34, 806 - 810

• A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells.

  Journal article

  Tarasov AI. et al, (2006), Diabetes, 55, 3075 - 3082

• Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels.

  Journal article

  Heusser K. et al, (2006), J Cell Sci, 119, 4353 - 4363

• ATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cells.

  Journal article

  Tarasov AI. et al, (2006), Diabetes, 55, 2446 - 2454

• Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

  Journal article

  Pearson ER. et al, (2006), N Engl J Med, 355, 467 - 477

• Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice.

  Journal article

  Freeman HC. et al, (2006), Diabetes, 55, 2153 - 2156

• Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

  Journal article

  Plum L. et al, (2006), J Clin Invest, 116, 1886 - 1901

• A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.

  Journal article

  Proks P. et al, (2006), Hum Mol Genet, 15, 1793 - 1800

• Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.

  Journal article

  Shimomura K. et al, (2006), Diabetes, 55, 1705 - 1712

• Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.

  Journal article

  Proks P. et al, (2006), Diabetes, 55, 1731 - 1737

• Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.

  Journal article

  Deacon RM. et al, (2006), Physiol Behav, 87, 723 - 733

• Behavioral phenotyping of mice lacking the K<inf>ATP</inf>channel subunit Kir6.2

  Journal article

  Deacon RMJ. et al, (2006), Physiology and Behavior, 87, 723 - 733

• K(ATP) channels and insulin secretion: a key role in health and disease.

  Journal article

  Ashcroft FM., (2006), Biochem Soc Trans, 34, 243 - 246

• From molecule to malady.

  Journal article

  Ashcroft FM., (2006), Nature, 440, 440 - 447

• Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels.

  Journal article

  Tammaro P. et al, (2006), J Physiol, 571, 3 - 14

• Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion.

  Journal article

  Freeman H. et al, (2006), Cell Metab, 3, 35 - 45

• 3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

  Journal article

  Mikhailov MV. et al, (2005), EMBO J, 24, 4166 - 4175

• Does Nicotinamide nucleotide transhydrogenase have a role in insulin secretion?

  Conference paper

  Freeman H. et al, (2005), GENETICAL RESEARCH, 86, 235 - 235

• Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.

  Journal article

  Proks P. et al, (2005), Hum Mol Genet, 14, 2717 - 2726

• Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy.

  Journal article

  Hattersley AT. and Ashcroft FM., (2005), Diabetes, 54, 2503 - 2513

• ATP-sensitive potassium channelopathies: focus on insulin secretion.

  Journal article

  Ashcroft FM., (2005), J Clin Invest, 115, 2047 - 2058

• Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions.

  Journal article

  Tammaro P. et al, (2005), EMBO J, 24, 2318 - 2330

• Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.

  Journal article

  Haider S. et al, (2005), J Mol Cell Cardiol, 38, 927 - 936

• Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.

  Journal article

  Haider S. et al, (2005), Biophys J, 88, 3310 - 3320

• A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.

  Journal article

  Proks P. et al, (2005), EMBO Rep, 6, 470 - 475

• Relapsing diabetes can result from moderately activating mutations in KCNJ11.

  Journal article

  Gloyn AL. et al, (2005), Hum Mol Genet, 14, 925 - 934

• A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.

  Journal article

  Toye AA. et al, (2005), Diabetologia, 48, 675 - 686

• Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.

  Journal article

  Hansen AM. et al, (2005), Br J Pharmacol, 144, 551 - 557

• Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

  Journal article

  Antcliff JF. et al, (2005), EMBO J, 24, 229 - 239

• Molecular basis of Kir6.2 mutations causing neonatal diabetes and neonatal diabetes with neurological features

  Conference paper

  Proks P. et al, (2005), BIOPHYSICAL JOURNAL, 88, 181A - 181A

• The role of nicotinamide nucleotide transhydrogenase in insulin secretion and impaired glucose tolerance

  Conference paper

  Freeman HC. et al, (2005), DIABETOLOGIA, 48, A103 - A103

• Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features.

  Journal article

  Proks P. et al, (2004), Proc Natl Acad Sci U S A, 101, 17539 - 17544

• Nucleotide-dependent conformational changes in HisP: molecular dynamics simulations of an ABC transporter nucleotide-binding domain.

  Journal article

  Campbell JD. et al, (2004), Biophys J, 87, 3703 - 3715

• Low-voltage-activated A-current controls the firing dynamics of mouse hypothalamic orexin neurons.

  Journal article

  Burdakov D. et al, (2004), Eur J Neurosci, 20, 3281 - 3285

• Inhibition of ATP-sensitive potassium channels by haloperidol.

  Journal article

  Yang SB. et al, (2004), Br J Pharmacol, 143, 960 - 967

• Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains.

  Conference paper

  Campbell JD. et al, (2004), Diabetes, 53 Suppl 3, S123 - S127

• Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.

  Journal article

  Dabrowski M. et al, (2004), J Physiol, 557, 347 - 354

• Molecular defects in insulin secretion in type-2 diabetes.

  Journal article

  Ashcroft FM. and Rorsman P., (2004), Rev Endocr Metab Disord, 5, 135 - 142

• Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.

  Journal article

  Gloyn AL. et al, (2004), N Engl J Med, 350, 1838 - 1849

• Inhibition of ATP-sensitive K+ channels by taurine through a benzamido-binding site on sulfonylurea receptor 1.

  Journal article

  Park EJ. et al, (2004), Biochem Pharmacol, 67, 1089 - 1096

• ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer.

  Journal article

  Tsuboi T. et al, (2004), Proc Natl Acad Sci U S A, 101, 76 - 81

• Characterisation of new K-ATP-channel mutations associated with congenital hyperinsulinism in the Finnish population (vol 46, pg 241, 2003)

  Journal article

  Reimann F. et al, (2004), DIABETOLOGIA, 47, 155 - 155

• Potassium channel regulation.

  Journal article

  Campbell JD. et al, (2003), EMBO Rep, 4, 1038 - 1042

• Potassium channel regulation. Structural insights into the function of the nucleotide-binding domains of the human sulphonylurea receptor

  Journal article

  Campbell JD. et al, (2003), EMBO Reports, 4, 1038 - 1042

• Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.

  Journal article

  Dabrowski M. et al, (2003), Diabetologia, 46, 1375 - 1382

• Functional coupling between Kir6.2 and SUR1 is prerequisite for [H-3]repaglinide, but not [H-3]glibenclamide, binding to pancreatic ATP-sensitive potassium (K-ATP) channels.

  Conference paper

  Hansen AK. et al, (2003), DIABETOLOGIA, 46, A161 - A161

• ATP-dependent interaction of the cytosolic domains of Kir6.2 revealed by fluorescence resonance energy transfer

  Conference paper

  Tsuboi T. et al, (2003), DIABETOLOGIA, 46, A161 - A161

• Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes.

  Journal article

  Dabrowski M. et al, (2003), J Physiol, 550, 357 - 363

• Crystal structure of the potassium channel KirBac1.1 in the closed state.

  Journal article

  Kuo A. et al, (2003), Science, 300, 1922 - 1926

• Identification of residues contributing to the ATP binding site of Kir6.2.

  Journal article

  Trapp S. et al, (2003), EMBO J, 22, 2903 - 2912

• Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger.

  Journal article

  Burdakov D. et al, (2003), J Neurosci, 23, 4951 - 4957

• Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.

  Journal article

  Capener CE. et al, (2003), Biophys J, 84, 2345 - 2356

• Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.

  Journal article

  Reimann F. et al, (2003), J Physiol, 547, 159 - 168

• Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population.

  Journal article

  Reimann F. et al, (2003), Diabetologia, 46, 241 - 249

• A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

  Journal article

  Huopio H. et al, (2003), Lancet, 361, 301 - 307

• The ligand-sensitive gate of a potassium channel lies close to the selectivity filter.

  Journal article

  Proks P. et al, (2003), EMBO Rep, 4, 70 - 75

• The ligand-sensitive gate of a potassium channel lies close to the selectivity filter

  Journal article

  Proks P. et al, (2003), EMBO Reports, 4, 70 - 75

• Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.

  Journal article

  Lippiat JD. et al, (2002), Diabetes, 51 Suppl 3, S377 - S380

• The ligand-sensitive gate of a potassium channel lies close to the selectivity filter

  Conference paper

  Proks P. et al, (2002), JOURNAL OF PHYSIOLOGY-LONDON, 544, 9P - 9P

• Mapping the architecture of the ATP-binding site of Kir6.2

  Conference paper

  Dabrowski M. and Ashcroft FM., (2002), JOURNAL OF PHYSIOLOGY-LONDON, 544, 9P - 9P

• Shedding new light on brain metabolism and glial function.

  Journal article

  Burdakov D. and Ashcroft FM., (2002), J Physiol, 544

• Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1.

  Journal article

  Hansen AM. et al, (2002), Diabetes, 51, 2789 - 2795

• Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31.

  Journal article

  Gros L. et al, (2002), Br J Pharmacol, 137, 98 - 106

• Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding.

  Journal article

  Matsuo M. et al, (2002), EMBO J, 21, 4250 - 4258

• Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-Type potassium channels.

  Journal article

  Burdakov D. and Ashcroft FM., (2002), J Neurosci, 22, 6380 - 6387

• Potent and selective activation of beta-cell Type ATP-sensitive potassium channels by NN414, a novel diazoxide analogue.

  Conference paper

  Wahl P. et al, (2002), DIABETOLOGIA, 45, A166 - A167

• The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.

  Journal article

  Dabrowski M. et al, (2002), Diabetes, 51, 1896 - 1906

• Different effects of insulin on electrically distinct hypothalamic arcuate nucleus (ARC) neurones

  Journal article

  Burdakov D. and Ashcroft FM., (2002), BIOPHYSICAL JOURNAL, 82, 626A - 626A

• Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.

  Journal article

  Jones PA. et al, (2001), FEBS Lett, 508, 85 - 89

• Structural basis for the interference between nicorandil and sulfonylurea action.

  Journal article

  Reimann F. et al, (2001), Diabetes, 50, 2253 - 2259

• Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.

  Journal article

  Proks P. et al, (2001), J Gen Physiol, 118, 341 - 353

• Dynamic sensitivity of ATP-sensitive K(+) channels to ATP.

  Journal article

  Loussouarn G. et al, (2001), J Biol Chem, 276, 29098 - 29103

• Interactions between nicorandil and sulphonylureas: a structural basis.

  Journal article

  Reimann F. et al, (2001), DIABETOLOGIA, 44, A68 - A68

• Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells.

  Journal article

  Lawrence CL. et al, (2001), Diabetologia, 44, 1019 - 1025

• Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels.

  Journal article

  Dabrowski M. et al, (2001), Diabetologia, 44, 747 - 756

• Time-dependent activation of KIR6.2/SUR2A channels but not KIR6.2/SUR1 channels in the presence of MgATP

  Journal article

  Song DK. and Ashcroft FM., (2001), JOURNAL OF PHYSIOLOGY-LONDON, 533, 118P - 119P

• Structure-function studies of the fast gating kinetics of the cloned ATP-sensitive potassium channel, Kir6.2/SUR1

  Journal article

  Proks P. et al, (2001), JOURNAL OF PHYSIOLOGY-LONDON, 533, 113P - 114P

• Probing the structure and function of the K-ATP channel with thiol reagents.

  Journal article

  Trapp S. et al, (2001), JOURNAL OF PHYSIOLOGY-LONDON, 533, 113P - 113P

• High-affinity block of K-ATP channels of mouse isolated pancreatic beta-cells but not rat heart or arterial smooth muscle cells by the sulphonylurea gliclazide

  Journal article

  Jones P. et al, (2001), JOURNAL OF PHYSIOLOGY-LONDON, 533, 116P - 116P

• Glimepiride block of Kir6.2/SUR1 Kir6.2/SUR2A and Kir6.2/SUR2A and Kir6.2/SUR2B K-ATP channels.

  Journal article

  Ashcroft FM. and Song DK., (2001), JOURNAL OF PHYSIOLOGY-LONDON, 533, 116P - 117P

• Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels.

  Journal article

  Song DK. and Ashcroft FM., (2001), Br J Pharmacol, 133, 193 - 199

• Differential activation of cloned K-ATP channels by nicorandil

  Journal article

  Reimann F. et al, (2001), JOURNAL OF PHYSIOLOGY-LONDON, 533, 114P - 114P

• A novel SUR1/Kir6.2 specific K-ATP channel opener

  Journal article

  Dabrowski M. et al, (2001), JOURNAL OF PHYSIOLOGY-LONDON, 533, 115P - 115P

• Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.

  Journal article

  Reimann F. et al, (2001), Br J Pharmacol, 132, 1542 - 1548

• ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit.

  Journal article

  Song DK. and Ashcroft FM., (2001), J Biol Chem, 276, 7143 - 7149

• Interaction of stilbene disulphonates with cloned K(ATP) channels.

  Journal article

  Proks P. et al, (2001), Br J Pharmacol, 132, 973 - 982

• Two types of gating in inward rectifiers: The case of the K-ATP channel.

  Journal article

  Proks P. et al, (2001), BIOPHYSICAL JOURNAL, 80, 512A - 512A

• Time-dependent activation of Kir6.2/SUR2A channels but not Kir6.2/SUR1 channels in the presence of ATP

  Journal article

  Ashcroft FM. and Song DK., (2001), BIOPHYSICAL JOURNAL, 80, 626A - 626A

• Dynamic sensitivity of K-ATP channels to ATP

  Journal article

  Loussouarn G. et al, (2001), BIOPHYSICAL JOURNAL, 80, 6A - 6A

• The ATP-sensitive potassium channel: a metabolic sensor

  Conference paper

  Ashcroft FM. and Trapp S., (2001), MOLECULAR MECHANISMS OF METABOLIC ARREST, 43 - 58

• Functional analysis of a mutant sulfonylurea receptor, SUR1-R1420C, that is responsible for persistent hyperinsulinemic hypoglycemia of infancy.

  Journal article

  Matsuo M. et al, (2000), J Biol Chem, 275, 41184 - 41191

• Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.

  Journal article

  Reimann F. et al, (2000), Mol Pharmacol, 58, 1318 - 1325

• The Yin and Yang of the K(ATP) channel.

  Journal article

  Ashcroft FM., (2000), J Physiol, 528

• New windows on the mechanism of action of K(ATP) channel openers.

  Journal article

  Ashcroft FM. and Gribble FM., (2000), Trends Pharmacol Sci, 21, 439 - 445

• Direct interaction of Na-azide with the KATP channel.

  Journal article

  Trapp S. and Ashcroft FM., (2000), Br J Pharmacol, 131, 1105 - 1112

• The antimalarial agent mefloquine inhibits ATP-sensitive K-channels.

  Journal article

  Gribble FM. et al, (2000), Br J Pharmacol, 131, 756 - 760

• Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues.

  Conference paper

  Gribble FM. and Ashcroft FM., (2000), Metabolism, 49, 3 - 6

• A novel method for measurement of submembrane ATP concentration.

  Journal article

  Gribble FM. et al, (2000), J Biol Chem, 275, 30046 - 30049

• Inhibition of cloned K-ATP channels by stilbene disulphonates

  Journal article

  Proks P. et al, (2000), JOURNAL OF PHYSIOLOGY-LONDON, 527, 114P - 114P

• Functional analysis of a mutant sulphonylurea receptor associated with a mild form of persistent hyperinsulinaemic hypoglycaemia of infancy

  Journal article

  Trapp S. et al, (2000), JOURNAL OF PHYSIOLOGY-LONDON, 527, 113P - 114P

• Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels.

  Journal article

  Ashcroft FM. and Gribble FM., (2000), J Diabetes Complications, 14, 192 - 196

• Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide.

  Journal article

  Tanabe K. et al, (2000), Biochem Biophys Res Commun, 272, 316 - 319

• Regulation of K-ATP channels by nucleotides and drugs

  Journal article

  Gribble FM. et al, (2000), JOURNAL OF PHYSIOLOGY-LONDON, 525, 27S - 28S

• Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.

  Journal article

  Gribble FM. et al, (2000), Mol Pharmacol, 57, 1256 - 1261

• Nucleotide modulation of pinacidil stimulation of cloned KATP channels

  Journal article

  Reimann F. et al, (2000), EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 455 - 455

• Quantal analysis of 5-hydroxytryptamine release from mouse pancreatic beta-cells.

  Journal article

  Smith PA. et al, (1999), J Physiol, 521 Pt 3, 651 - 664

• Altered functional properties of KATP channel conferred by a novel splice variant of SUR1.

  Journal article

  Sakura H. et al, (1999), J Physiol, 521 Pt 2, 337 - 350

• Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.

  Journal article

  Tucker SJ. and Ashcroft FM., (1999), J Biol Chem, 274, 33393 - 33397

• The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.

  Journal article

  Reimann F. et al, (1999), J Physiol, 520 Pt 3, 661 - 669

• In vitro mechanism of action on insulin release of S-22068, a new putative antidiabetic compound.

  Journal article

  Le Brigand L. et al, (1999), Br J Pharmacol, 128, 1021 - 1026

• NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1.

  Journal article

  Matsuo M. et al, (1999), FEBS Lett, 458, 292 - 294

• Interaction of vanadate with the cloned beta cell K(ATP) channel.

  Journal article

  Proks P. et al, (1999), J Biol Chem, 274, 25393 - 25397

• Inwardly rectifying potassium channels.

  Journal article

  Reimann F. and Ashcroft FM., (1999), Curr Opin Cell Biol, 11, 503 - 508

• ATP-sensitive K+ channels and insulin secretion: their role in health and disease.

  Journal article

  Ashcroft FM. and Gribble FM., (1999), Diabetologia, 42, 903 - 919

• Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.

  Journal article

  Reimann F. et al, (1999), J Physiol, 518 ( Pt 2), 325 - 336

• Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.

  Journal article

  Gribble FM. and Ashcroft FM., (1999), Diabetologia, 42, 845 - 848

• Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.

  Journal article

  Ashfield R. et al, (1999), Diabetes, 48, 1341 - 1347

• Miniglucagon (glucagon 19-29), a potent and efficient inhibitor of secretagogue-induced insulin release through a Ca2+ pathway.

  Journal article

  Dalle S. et al, (1999), J Biol Chem, 274, 10869 - 10876

• Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.

  Journal article

  Tanabe K. et al, (1999), J Biol Chem, 274, 3931 - 3933

• A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland.

  Journal article

  Otonkoski T. et al, (1999), Diabetes, 48, 408 - 415

• Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.

  Journal article

  Proks P. et al, (1999), J Physiol, 514 ( Pt 1), 19 - 25

• The N-terminus of Kir6.2 is involved in coupling to SUR1

  Poster

  Reimann F. et al, (1999)

• Identification of the high affinity tolbutamide site on the SUR1 subunit of the K-ATP channel

  Journal article

  Gribble FM. et al, (1999), BIOPHYSICAL JOURNAL, 76, A14 - A14

• Ion channels - Exciting times for PIP2

  Journal article

  Ashcroft FM., (1998), SCIENCE, 282, 1059 - 1060

• Exciting times for PIP2.

  Journal article

  Ashcroft FM., (1998), Science, 282, 1059 - 1060

• Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA.

  Journal article

  Gribble FM. et al, (1998), J Biol Chem, 273, 26383 - 26387

• Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels.

  Journal article

  Gribble FM. et al, (1998), Diabetes, 47, 1412 - 1418

• Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

  Journal article

  Trapp S. et al, (1998), J Gen Physiol, 112, 333 - 349

• Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification.

  Journal article

  Trapp S. et al, (1998), J Gen Physiol, 112, 325 - 332

• Stimulation of insulin release by a new compound S-22068. Evidence for a novel imidazoline binding site in beta cells

  Journal article

  Le Brigand L. et al, (1998), DIABETOLOGIA, 41, A151 - A151

• Mechanism of K-ATP channel inhibition by ATP

  Journal article

  Ashcroft FM. et al, (1998), DIABETOLOGIA, 41, A14 - A14

• Interaction of MgATP with the sulphonylurea subunit activates ATP sensitive K-channels receptor

  Journal article

  Gribble FM. et al, (1998), DIABETOLOGIA, 41, A13 - A13

• Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties.

  Journal article

  Heron L. et al, (1998), Proc Natl Acad Sci U S A, 95, 8387 - 8391

• Correlating structure and function in ATP-sensitive K+ channels.

  Journal article

  Ashcroft FM. and Gribble FM., (1998), Trends Neurosci, 21, 288 - 294

• Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus.

  Journal article

  Mikhailov MV. et al, (1998), FEBS Lett, 429, 390 - 394

• Molecular determinants of KATP channel inhibition by ATP.

  Journal article

  Tucker SJ. et al, (1998), EMBO J, 17, 3290 - 3296

• MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.

  Journal article

  Gribble FM. et al, (1998), Proc Natl Acad Sci U S A, 95, 7185 - 7190

• Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.

  Journal article

  Sakura H. et al, (1998), Diabetologia, 41, 654 - 659

• A touching case of channel regulation: the ATP-sensitive K+ channel.

  Journal article

  Tucker SJ. and Ashcroft FM., (1998), Curr Opin Neurobiol, 8, 316 - 320

• Modulation of gating of the cloned beta-cell K-ATP channel

  Poster

  Proks P. et al, (1998)

• Gating and ATP-sensitivity of the cloned beta-cell K-ATP channel

  Journal article

  Trapp S. et al, (1998), BIOPHYSICAL JOURNAL, 74, A218 - A218

• Electrophysiological and metabolic characterization of single beta-cells and islets from diabetic GK rats.

  Journal article

  Hughes SJ. et al, (1998), Diabetes, 47, 73 - 81

• A metabolic sensor in action: News from the ATP-sensitive K⁺-channel

  Journal article

  Trapp S. and Ashcroft FM., (1997), News in Physiological Sciences, 12, 255 - 262

• Phentolamine block of ATP-sensitive K+ channels does not involve interaction with the sulphonylurea receptor, SUR1.

  Journal article

  Proks P. and Ashcroft FM., (1997), JOURNAL OF PHYSIOLOGY-LONDON, 504P, P155 - P156

• Phentolamine block of KATP channels is mediated by Kir6.2.

  Journal article

  Proks P. and Ashcroft FM., (1997), Proc Natl Acad Sci U S A, 94, 11716 - 11720

• The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation.

  Journal article

  Gribble FM. et al, (1997), J Physiol, 504 ( Pt 1), 35 - 45

• Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits.

  Journal article

  Trapp S. et al, (1997), Proc Natl Acad Sci U S A, 94, 8872 - 8877

• The antimalarial drugs mefloquine and halofantrine inhibit ATP-sensitive potassium channels

  Journal article

  Gribble FM. et al, (1997), DIABETOLOGIA, 40, 401 - 401

• Interactions between tolbutamide and nucleotides on cloned K-ATP channels.

  Poster

  Gribble FM. et al, (1997)

• High expression of trp, a putative calcium-release activated channel in mouse insulinoma cells

  Journal article

  Sakura H. and Ashcroft FM., (1997), DIABETOLOGIA, 40, 392 - 392

• Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.

  Journal article

  Tucker SJ. et al, (1997), Nature, 387, 179 - 183

• Identification of four trp1 gene variants murine pancreatic beta-cells.

  Journal article

  Sakura H. and Ashcroft FM., (1997), Diabetologia, 40, 528 - 532

• The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.

  Journal article

  Gribble FM. et al, (1997), EMBO J, 16, 1145 - 1152

• Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells.

  Journal article

  Smith PA. et al, (1997), J Physiol, 499 ( Pt 3), 625 - 635

• Malate transport and vacuolar ion channels in CAM plants.

  Conference paper

  Cheffings CM. et al, (1997), J Exp Bot, 48 Spec No, 623 - 631

• Thiol reagents and ATP do not interact with C717 in the SUR1 subunit of the beta-cell K-ATP channel

  Poster

  Trapp S. et al, (1997)

• MgADP hydrolysis is required for MgADP activation of the cloned beta-cell K-ATP channel expressed in Xenopus oocytes

  Poster

  Gribble FM. et al, (1997)

• Dual effects of Na-azide on the whole-cell K-ATP current in isolated mouse pancreatic beta-cells

  Journal article

  Trapp S. et al, (1997), JOURNAL OF PHYSIOLOGY-LONDON, 499P, P11 - P12

• A model for regulation of the beta-cell ATP-sensitive K+-channel by nucleotides and diazoxide.

  Journal article

  Tucker SJ. et al, (1997), BIOPHYSICAL JOURNAL, 72, WPO16 - WPO16

• Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain.

  Journal article

  Karschin C. et al, (1997), FEBS Lett, 401, 59 - 64

• Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes.

  Journal article

  Gribble FM. et al, (1997), J Physiol, 498 ( Pt 1), 87 - 98

• Heterogeneity of beta-cell secretion. Possible involvement of K-ATP channels.

  Journal article

  Faehling M. and Ashcroft FM., (1997), Adv Exp Med Biol, 426, 247 - 252

• Heterogeneity of beta-cell Ca2+ responses to glucose.

  Conference paper

  Smith P. et al, (1997), Adv Exp Med Biol, 426, 253 - 257

• Effects of protein phosphorylation on the sulphonylurea receptor of the pancreatic beta-cell.

  Journal article

  Niki I. et al, (1997), Adv Exp Med Biol, 426, 59 - 69

• Sweet news for hypoglycemic babies.

  Journal article

  Ashcroft FM., (1996), Nat Med, 2, 1301 - 1302

• Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps.

  Journal article

  Proks P. et al, (1996), J Physiol, 496 ( Pt 1), 255 - 264

• Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro.

  Journal article

  Sakura H. et al, (1996), Diabetologia, 39, 1233 - 1236

• Mechanisms of the glycaemic effects of sulfonylureas.

  Journal article

  Ashcroft FM., (1996), Horm Metab Res, 28, 456 - 463

• The sulphonylurea receptor confers diazoxide sensitivity on the inwardly rectifying K+ channel Kir6.1 expressed in human embryonic kidney cells.

  Journal article

  Ammälä C. et al, (1996), J Physiol, 494 ( Pt 3), 709 - 714

• Screening for mutations in the Kir6.2 subunit of the beta-cell K-ATP channel

  Journal article

  Sakura H. et al, (1996), DIABETOLOGIA, 39, 275 - 275

• Protein kinase C does not influence the tolbutamide sensitivity of K-ATP currents

  Journal article

  Proks P. et al, (1996), DIABETOLOGIA, 39, 105 - 105

• Modulation of tolbutamide sensitivity of K-ATP currents in mouse pancreatic beta-cells by intracellular nucleotides and magnesium

  Journal article

  Faehling M. et al, (1996), DIABETOLOGIA, 39, 454 - 454

• Expression of the cloned beta-cell ATP-sensitive potassium channel in Xenopus oocytes

  Journal article

  Gribble FM. et al, (1996), DIABETOLOGIA, 39, 433 - 433

• Heteromeric channel formation and Ca(2+)-free media reduce the toxic effect of the weaver Kir 3.2 allele.

  Journal article

  Tucker SJ. et al, (1996), FEBS Lett, 390, 253 - 257

• Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium.

  Journal article

  Eliasson L. et al, (1996), J Physiol, 493 ( Pt 3), 755 - 767

• Exocytosis in isolated mouse pancreatic beta-cells

  Journal article

  Ashcroft FM. et al, (1996), JOURNAL OF PHYSIOLOGY-LONDON, 493P, S146 - S147

• Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels.

  Journal article

  Ammälä C. et al, (1996), Nature, 379, 545 - 548

• The Ba2+ block of the ATP-sensitive K+ current of mouse pancreatic beta-cells.

  Journal article

  Takano M. and Ashcroft FM., (1996), Pflugers Arch, 431, 625 - 631

• Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle.

  Journal article

  Sakura H. et al, (1995), FEBS Lett, 377, 338 - 344

• INWARDLY RECTIFYING K+ CURRENTS IN OOCYTES CO-EXPRESSING KIR3.1 AND KIR3.2

  Journal article

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• CHARACTERIZATION OF AN INWARDLY RECTIFYING K+ CHANNEL EXPRESSED IN PANCREATIC BETA-CELLS

  Journal article

  ASHCROFT F., (1995), JOURNAL OF PHYSIOLOGY-LONDON, 489P, S8 - S9

• Effects of divalent cations on exocytosis and endocytosis from single mouse pancreatic beta-cells.

  Journal article

  Proks P. and Ashcroft FM., (1995), J Physiol, 487 ( Pt 2), 465 - 477

• MOBILIZATION OF INTRACELLULAR CALCIUM BY CAFFEINE IN SINGLE-MOUSE PANCREATIC BETA-CELLS

  Journal article

  CHAPMAN S. et al, (1995), JOURNAL OF PHYSIOLOGY-LONDON, 487P, P12 - P13

• EFFECT OF L-NMMA, CROMAKALIM, AND GLIBENCLAMIDE ON CEREBRAL BLOOD-FLOW IN HYPERCAPNIA AND HYPOXIA

  Journal article

  REID J. et al, (1995), AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 269, H916 - H922

• Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia.

  Journal article

  Reid JM. et al, (1995), Am J Physiol, 269, H916 - H922

• DIFFERENT TYPES OF MEMBRANE RETRIEVAL IN SINGLE-MOUSE PANCREATIC BETA-CELLS

  Journal article

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• A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic beta-cells.

  Journal article

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• 2 CATIONIC AMINO-ACID TRANSPORTERS EXPRESSED IN PANCREATIC BETA-CELLS

  Journal article

  ASHCROFT F. et al, (1995), JOURNAL OF PHYSIOLOGY-LONDON, 487P, P192 - P193

• CATIONIC AMINO-ACID TRANSPORTERS EXPRESSED IN PANCREATIC BETA-CELLS

  Journal article

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• No evidence for mutations in a putative subunit of the beta-cell ATP-sensitive potassium channel (K-ATP channel) in Japanese NIDDM patients.

  Journal article

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• Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit.

  Journal article

  Sakura H. et al, (1995), FEBS Lett, 367, 193 - 197

• Cloning and functional expression of the cDNA encoding an inwardly-rectifying potassium channel expressed in pancreatic beta-cells and in the brain.

  Journal article

  Bond CT. et al, (1995), FEBS Lett, 367, 61 - 66

• NO EVIDENCE FOR MUTATIONS IN THE BETA-CELL ATP-SENSITIVE POTASSIUM CHANNEL IN MODY, NIDDM OR GESTATIONAL DIABETES

  Journal article

  ZHANG Y. et al, (1995), DIABETES, 44, A235 - A235

• No evidence for mutations in a putative beta-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM.

  Journal article

  Zhang Y. et al, (1995), Diabetes, 44, 597 - 600

• Metabolic inhibition and low internal ATP activate K-ATP channels in rat dopaminergic substantia nigra neurones.

  Journal article

  Röper J. and Ashcroft FM., (1995), Pflugers Arch, 430, 44 - 54

• EXOCYTOSIS MONITORED BY SIMULTANEOUS MEASUREMENT OF CELL CAPACITANCE AND 5-HT RELEASE IN ISOLATED MOUSE PANCREATIC BETA-CELLS

  Journal article

  SMITH P. et al, (1994), JOURNAL OF PHYSIOLOGY-LONDON, 480P, P123 - P124

• Effects of internal chloride on ATP-sensitive K-channels in mouse pancreatic beta-cells.

  Journal article

  Takano M. and Ashcroft FM., (1994), Pflugers Arch, 428, 194 - 196

• EFFECTS OF DIVALENT-CATIONS ON SECRETION FROM ISOLATED MOUSE PANCREATIC BETA-CELLS

  Journal article

  ASHCROFT F. and PROKS P., (1994), DIABETOLOGIA, 37, A107 - A107

• CORRELATION OF INTERNAL CALCIUM TRANSIENTS, EXOCYTOSIS AND THE RELEASE OF GRANULE CONTENTS IN PANCREATIC BETA-CELLS

  Journal article

  SMITH P. et al, (1994), DIABETOLOGIA, 37, A70 - A70

• CA-INDEPENDENT STIMULATION OF EXOCYTOSIS BY GTP IN SINGLE-MOUSE PANCREATIC BETA-CELLS

  Journal article

  PROKS P. and ASHCROFT F., (1994), DIABETOLOGIA, 37, A76 - A76

• Differential expression of the inwardly-rectifying K-channel ROMK1 in rat brain.

  Journal article

  Kenna S. et al, (1994), Brain Res Mol Brain Res, 24, 353 - 356

• The KATP and Kv channels are distinct entities: a reply to Edwards and Weston.

  Journal article

  Ashcroft FM. et al, (1994), Cardiovasc Res, 28, 738 - 740

• Block of ATP-sensitive K+ channels in isolated mouse pancreatic beta-cells by 2,3-butanedione monoxime.

  Journal article

  Smith PA. et al, (1994), Br J Pharmacol, 112, 143 - 149

• Effects of intracellular pH on ATP-sensitive K+ channels in mouse pancreatic beta-cells.

  Journal article

  Proks P. et al, (1994), J Physiol, 475, 33 - 44

• VOLTAMMETRIC MONITORING OF 5-HT SECRETION FROM ISOLATED MOUSE PANCREATIC BETA-CELLS

  Journal article

  SMITH P. et al, (1994), JOURNAL OF PHYSIOLOGY-LONDON, 475P, P157 - P157

• OXIDATIVE STRESS REDUCES FAST INACTIVATION OF AN A-CURRENT IN ISOLATED DOPAMINERGIC SUBSTANTIA-NIGRA NEURONS FROM RAT

  Journal article

  ROPER J. and ASHCROFT F., (1994), JOURNAL OF PHYSIOLOGY-LONDON, 475P, P144 - P144

• Determination of the molecular mass of the native beta-cell sulfonylurea receptor.

  Journal article

  Skeer JM. et al, (1994), FEBS Lett, 338, 98 - 102

• Stimulus-secretion coupling in pancreatic beta cells.

  Journal article

  Ashcroft FM. et al, (1994), J Cell Biochem, 55 Suppl, 54 - 65

• Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells.

  Journal article

  Ammälä C. et al, (1993), J Physiol, 472, 665 - 688

• The effect of tolbutamide on cerebral blood flow during hypoxia and hypercapnia in the anaesthetized rat.

  Journal article

  Reid JM. et al, (1993), Pflugers Arch, 425, 362 - 364

• Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells.

  Journal article

  Duchen MR. et al, (1993), Biochem J, 294 ( Pt 1), 35 - 42

• Transporters, channels and human disease.

  Journal article

  Ashcroft FM. and Röper J., (1993), Curr Opin Cell Biol, 5, 677 - 683

• THE EFFECT OF INTRACELLULAR PROTONS ON ATP-SENSITIVE K+ CHANNELS IN MOUSE PANCREATIC BETA-CELLS

  Journal article

  PROKS P. et al, (1993), DIABETOLOGIA, 36, A60 - A60

• IMPAIRED BETA-CELL FUNCTION BUT NOT SELECTIVE GLUCOSE INSENSITIVITY IN DIET-TREATED TYPE-2 DIABETIC SUBJECTS

  Journal article

  CAMPS I. et al, (1993), DIABETOLOGIA, 36, A74 - A74

• DETERMINATION OF THE MOLECULAR-MASS OF THE BETA-CELL SULFONYLUREA RECEPTOR

  Journal article

  SKEER J. et al, (1993), DIABETOLOGIA, 36, A74 - A74

• Modification of K-ATP channels in pancreatic beta-cells by trypsin.

  Journal article

  Proks P. and Ashcroft FM., (1993), Pflugers Arch, 424, 63 - 72

• Calcium-independent potentiation of insulin release by cyclic AMP in single beta-cells.

  Journal article

  Ammälä C. et al, (1993), Nature, 363, 356 - 358

• Two types of potassium channel regulated by ATP in pancreatic B cells isolated from a type-2 diabetic human.

  Journal article

  Williams BA. et al, (1993), Pflugers Arch, 423, 265 - 273

• Permeation and gating properties of the L-type calcium channel in mouse pancreatic beta cells.

  Journal article

  Smith PA. et al, (1993), J Gen Physiol, 101, 767 - 797

• THE EFFECT OF INTRACELLULAR PH ON ATP-SENSITIVE K+ CHANNELS IN ISOLATED MOUSE PANCREATIC BETA-CELLS

  Journal article

  PROKS P. et al, (1993), JOURNAL OF PHYSIOLOGY-LONDON, 467, P267 - P267

• The beta-cell sulfonylurea receptor.

  Journal article

  Ashcroft SJ. et al, (1993), Adv Exp Med Biol, 334, 47 - 61

• SUBSTRATE-DEPENDENT CHANGES IN MITOCHONDRIAL-FUNCTION, [CA-2+]I AND KATP CHANNELS IN MOUSE PANCREATIC BETA-CELLS INVITRO

  Journal article

  DUCHEN M. et al, (1993), JOURNAL OF PHYSIOLOGY-LONDON, 459, P266 - P266

• REDUCED INTERNAL ATP CONCENTRATIONS AND MITOCHONDRIAL INHIBITION ACTIVATE K+-ATP CHANNELS IN ISOLATED DOPAMINERGIC SUBSTANTIA-NIGRA NEURONS FROM THE RAT

  Journal article

  ROPER J. and ASHCROFT F., (1993), JOURNAL OF PHYSIOLOGY-LONDON, 473, P32 - P32

• BLOCK OF ATP-SENSITIVE K+ CHANNELS IN ISOLATED MOUSE PANCREATIC BETA-CELLS BY 2,3-BUTANEDIONE MONOXIME

  Journal article

  SMITH P. et al, (1993), JOURNAL OF PHYSIOLOGY-LONDON, 467, P265 - P265

• The sulfonylurea receptor.

  Journal article

  Ashcroft SJ. and Ashcroft FM., (1992), Biochim Biophys Acta, 1175, 45 - 59

• RUNDOWN OF ATP-SENSITIVE K-CURRENTS IN MOUSE PANCREATIC BETA-CELLS

  Journal article

  WILLIAMS B. and ASHCROFT F., (1992), DIABETOLOGIA, 35, A121 - A121

• HUMAN PANCREATIC B-CELLS POSSESS 2 TYPES OF CA-CHANNEL

  Journal article

  SMITH P. et al, (1992), DIABETOLOGIA, 35, A121 - A121

• EFFECTS OF TRYPSIN ON ATP-DEPENDENT-K+ CHANNELS FROM PANCREATIC BETA-CELLS

  Journal article

  PROKS P. and ASHCROFT F., (1992), DIABETOLOGIA, 35, A117 - A117

• DUAL EFFECTS OF PROTEIN-PHOSPHORYLATION ON THE BINDING-ACTIVITY OF THE SULFONYLUREA RECEPTOR

  Journal article

  NIKI I. et al, (1992), DIABETOLOGIA, 35, A111 - A111

• Ca²⁺-activated K⁺ channels from an insulin-secreting cell line incorporated into planar lipid bilayers

  Journal article

  Oosawa Y. et al, (1992), Diabetologia, 35, 619 - 623

• Ca(2+)-activated K+ channels from an insulin-secreting cell line incorporated into planar lipid bilayers.

  Journal article

  Oosawa Y. et al, (1992), Diabetologia, 35, 619 - 623

• Voltage-activated calcium and potassium currents in human pancreatic beta-cells.

  Journal article

  Kelly RP. et al, (1991), J Physiol, 443, 175 - 192

• Amantadine and sparteine inhibit ATP-regulated K-currents in the insulin-secreting beta-cell line, HIT-T15.

  Journal article

  Ashcroft FM. et al, (1991), Br J Pharmacol, 104, 579 - 584

• Ca2+ channels and excitation-contraction coupling.

  Journal article

  Ashcroft FM., (1991), Curr Opin Cell Biol, 3, 671 - 675

• Regulation of glucagon release from pancreatic A-cells.

  Journal article

  Rorsman P. et al, (1991), Biochem Pharmacol, 41, 1783 - 1790

• Ba currents through L-type Ca channels in isolated mouse pancreatic β-cells

  Journal article

  Smith PA. et al, (1991), Journal of Physiology, 434

• Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.

  Journal article

  Bokvist K. et al, (1991), Proc Biol Sci, 243, 139 - 144

• Identification and electrophysiology of isolated pars compacta neurons from guinea-pig substantia nigra.

  Journal article

  Hainsworth AH. et al, (1991), Neuroscience, 43, 81 - 93

• L-TYPE CA-CHANNEL ACTIVITY RECORDED AT A LOW DIVALENT-CATION CONCENTRATION

  Conference paper

  ASHCROFT F. et al, (1991), BIOMEDICAL RESEARCH-TOKYO, 12, 61 - 63

• ATP-sensitive K channels in guinea-pig isolated substantia nigra neurones are modulated by cellular metabolism

  Journal article

  Roper J. et al, (1990), Journal of Physiology, 430

• ATP-regulated K channels modulate electrical activity in mouse isolated pancreatic β-cells

  Journal article

  Ashcroft FM. et al, (1990), Journal of Physiology, 424

• Tolbutamide reverses membrane hyperpolarisation induced by activation of D2 receptors and GABAB receptors in isolated substantia nigra neurones.

  Journal article

  Roeper J. et al, (1990), Pflugers Arch, 416, 473 - 475

• Expression of voltage-gated K+ channels in insulin-producing cells. Analysis by polymerase chain reaction.

  Journal article

  Betsholtz C. et al, (1990), FEBS Lett, 263, 121 - 126

• Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells.

  Journal article

  Smith PA. et al, (1990), FEBS Lett, 261, 187 - 190

• THE ROLE OF ION CHANNELS IN STIMULUS-SECRETION COUPLING IN PANCREATIC BETA-CELLS

  Journal article

  ASHCROFT F. et al, (1990), BIOPHYSICAL JOURNAL, 57, A196 - A196

• ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion.

  Conference paper

  Ashcroft FM. and Rorsman P., (1990), Biochem Soc Trans, 18, 109 - 111

• Two types of Ca channel in rat pancreatic beta-cells.

  Journal article

  Ashcroft FM. et al, (1990), Pflugers Arch, 415, 504 - 506

• Properties and functions of ATP-sensitive K-channels.

  Journal article

  Ashcroft SJ. and Ashcroft FM., (1990), Cell Signal, 2, 197 - 214

• Tolbutamide reverses hypoglycaemia-induced hyperpolarization in guinea-pig isolated substantia nigra neurones

  Journal article

  Roeper J. et al, (1990), Journal of Physiology, 426

• Isolation and characterization of single neurones from guinea-pig substantia nigra

  Journal article

  Hainsworth AH. et al, (1990), Journal of Physiology, 430

• Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells.

  Journal article

  Smith PA. et al, (1989), Nature, 342, 550 - 553

• The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na,K-ATPase in intact HIT-T15 beta-cells.

  Journal article

  Niki I. et al, (1989), FEBS Lett, 257, 361 - 364

• GLUCOSE MODULATES L-TYPE CA CHANNELS IN MURINE ISOLATED PANCREATIC BETA-CELLS

  Journal article

  ASHCROFT F. and SMITH P., (1989), JOURNAL OF PHYSIOLOGY-LONDON, 417, P79 - P79

• ATP-sensitive K-channels in HIT T15 beta-cells studied by patch-clamp methods, 86Rb efflux and glibenclamide binding.

  Journal article

  Niki I. et al, (1989), Pflugers Arch, 415, 47 - 55

• ATP-sensitive K+ channels in rat pancreatic beta-cells: modulation by ATP and Mg2+ ions.

  Journal article

  Ashcroft FM. and Kakei M., (1989), J Physiol, 416, 349 - 367

• VOLTAGE-ACTIVATED CALCIUM AND POTASSIUM CURRENTS IN HUMAN ISOLATED PANCREATIC BETA-CELLS

  Journal article

  ASHCROFT F. et al, (1989), JOURNAL OF PHYSIOLOGY-LONDON, 415, P26 - P26

• The ATP- and tolbutamide-sensitivity of the ATP-sensitive K-channel from human pancreatic B cells.

  Journal article

  Ashcroft FM. et al, (1989), Diabetologia, 32, 591 - 598

• THE EFFECT OF CHANGES IN INTRACELLULAR ATP CONCENTRATION ON THE ACTIVITIES OF ATP-SENSITIVE K-CHANNELS AND OF NA-K-ATPASE IN INTACT HIT-T15 B-CELLS

  Journal article

  NIKI I. et al, (1989), DIABETOLOGIA, 32, A523 - A523

• MODULATION OF L-TYPE CA CHANNELS IN MURINE PANCREATIC B-CELLS BY GLUCOSE-METABOLISM

  Journal article

  SMITH P. and ASHCROFT F., (1989), DIABETOLOGIA, 32, A542 - A543

• SINGLE CALCIUM-CHANNEL ACTIVITY IN MOUSE PANCREATIC BETA-CELLS

  Journal article

  ASHCROFT F. et al, (1989), ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 560, 410 - 412

• Rubidium and sodium permeability of the ATP-sensitive K+ channel in single rat pancreatic beta-cells.

  Journal article

  Ashcroft FM. et al, (1989), J Physiol, 408, 413 - 429

• THE ROLE OF THE ATP-SENSITIVE K-CHANNEL IN STIMULUS-RESPONSE COUPLING IN THE PANCREATIC BETA-CELL

  Conference paper

  ASHCROFT S. and ASHCROFT F., (1989), HORMONES AND CELL REGULATION //, 198, 99 - 103

• Single calcium channel activity in mouse pancreatic beta-cells.

  Conference paper

  Ashcroft FM. et al, (1989), Ann N Y Acad Sci, 560, 410 - 412

• Electrophysiology of the pancreatic beta-cell.

  Journal article

  Ashcroft FM. and Rorsman P., (1989), Prog Biophys Mol Biol, 54, 87 - 143

• Calcium Currents in Insulin‐Secreting β‐Cells

  Journal article

  FINDLAY I. et al, (1989), Annals of the New York Academy of Sciences, 560, 403 - 409

• Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting beta-cell line, HIT T15.

  Journal article

  Ashcroft FM. et al, (1988), FEBS Lett, 239, 185 - 189

• Single Ca channel currents in mouse pancreatic B-cells.

  Journal article

  Rorsman P. et al, (1988), Pflugers Arch, 412, 597 - 603

• SINGLE CALCIUM-CHANNEL CURRENTS IN MOUSE PANCREATIC B-CELLS

  Journal article

  ASHCROFT F. et al, (1988), DIABETOLOGIA, 31, A465 - A466

• ATP-SENSITIVE K-CHANNELS IN HIT-T15 INSULIN SECRETING CELLS

  Journal article

  KELLY R. and ASHCROFT F., (1988), DIABETOLOGIA, 31, A507 - A508

• Properties of single potassium channels modulated by glucose in rat pancreatic beta-cells.

  Journal article

  Ashcroft FM. et al, (1988), J Physiol, 400, 501 - 527

• EFFECTS OF MAGNESIUM-IONS ON ATP-SENSITIVE K-CHANNELS FROM RAT PANCREATIC B-CELLS

  Journal article

  ASHCROFT F. and KAKEI M., (1988), BIOPHYSICAL JOURNAL, 53, A547 - A547

• Adenosine 5'-triphosphate-sensitive potassium channels.

  Journal article

  Ashcroft FM., (1988), Annu Rev Neurosci, 11, 97 - 118

• TOLBUTAMIDE, AN INHIBITOR OF ATP-SENSITIVE K-CHANNELS, EXCITES CAROTID-BODY CHEMORECEPTORS IN THE CAT

  Journal article

  ASHCROFT F. and ODONNELL J., (1987), JOURNAL OF PHYSIOLOGY-LONDON, 394, P66 - P66

• EFFECTS OF INTERNAL MG-2+ ON ATP-SENSITIVE K-CHANNELS IN ISOLATED RAT PANCREATIC B-CELLS

  Journal article

  ASHCROFT F. and KAKEI M., (1987), JOURNAL OF PHYSIOLOGY-LONDON, 390, P72 - P72

• CELL-ATTACHED PATCH RECORDINGS FROM SINGLE CELLS ISOLATED FROM GUINEA-PIG SUBSTANTIA-NIGRA

  Journal article

  ASHCROFT F. and KAPOOR R., (1987), JOURNAL OF PHYSIOLOGY-LONDON, 390, P77 - P77

• SINGLE CHANNEL RECORDINGS FROM HUMAN ISOLATED PANCREATIC B-CELLS

  Journal article

  KAKEI M. et al, (1987), DIABETOLOGIA, 30, A537 - A537

• FURTHER-STUDIES OF ATP-MODULATION OF K-CHANNELS IN RAT ISOLATED PANCREATIC-B CELLS

  Journal article

  ASHCROFT F. and KAKEI M., (1987), DIABETOLOGIA, 30, A495 - A495

• A microflow superfusion system for use with excised membrane patches.

  Journal article

  Kakei M. and Ashcroft FM., (1987), Pflugers Arch, 409, 337 - 341

• ATP-sensitive K+ channels in human isolated pancreatic B-cells.

  Journal article

  Ashcroft FM. et al, (1987), FEBS Lett, 215, 9 - 12

• Effects of 2-ketoisocaproate on insulin release and single potassium channel activity in dispersed rat pancreatic beta-cells.

  Journal article

  Ashcroft FM. et al, (1987), J Physiol, 385, 517 - 529

• ADP MODULATES THE ATP-SENSITIVITY OF THE K-CHANNEL CLOSED BY GLUCOSE IN ISOLATED RAT PANCREATIC B-CELLS

  Journal article

  ASHCROFT F. et al, (1986), JOURNAL OF PHYSIOLOGY-LONDON, 381, P68 - P68

• The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP.

  Journal article

  Kakei M. et al, (1986), FEBS Lett, 208, 63 - 66

• RUBIDIUM ACTS AS A PERMEANT BLOCKER OF THE GLUCOSE AND ATP-SENSITIVE K-CHANNEL IN RAT PANCREATIC BETA-CELLS

  Journal article

  ASHCROFT F. et al, (1986), JOURNAL OF PHYSIOLOGY-LONDON, 377, P38 - P38

• PERMEABILITY OF SINGLE GLUCOSE-SENSITIVE K-CHANNEL TO RUBIDIUM IONS

  Journal article

  ASHCROFT F. et al, (1986), DIABETOLOGIA, 29, A514 - A514

• Inward rectification in the transverse tubular system of frog skeletal muscle studied with potentiometric dyes.

  Journal article

  Ashcroft FM. et al, (1985), J Physiol, 359, 269 - 291

• THE GLUCOSE-SENSITIVE POTASSIUM CHANNEL IN RAT PANCREATIC BETA-CELLS IS INHIBITED BY INTRACELLULAR ATP

  Journal article

  ASHCROFT F. et al, (1985), JOURNAL OF PHYSIOLOGY-LONDON, 369, P101 - P101

• GLUCOSE INHIBITS POTASSIUM CHANNEL ACTIVITY IN SINGLE-RAT PANCREATIC-ISLET CELLS

  Journal article

  ASHCROFT F. et al, (1985), JOURNAL OF PHYSIOLOGY-LONDON, 358, P88 - P88

• Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells.

  Journal article

  Ashcroft FM. et al, (1984), Nature, 312, 446 - 448

• Ion channels in lymphocytes.

  Journal article

  Ashcroft FM., (1984), Immunol Today, 5, 232 - 233

• INWARD RECTIFICATION IN FROG-MUSCLE - FURTHER ANALYSIS OF ITS EFFECT ON RADIAL POTENTIAL SPREAD

  Journal article

  HEINY J. et al, (1984), BIOPHYSICAL JOURNAL, 45, A231 - A231

• INWARD RECTIFICATION IN THE T-SYSTEM OF FROG SKELETAL-MUSCLE

  Journal article

  HEINY J. et al, (1983), BIOPHYSICAL JOURNAL, 41, A394 - A394

Recent Publications

• Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

  Journal article

  Ashcroft FM. et al, (2017), Cell Metab, 26, 17 - 23

• Neonatal Diabetes and the KATP Channel: From Mutation to Therapy.

  Journal article

  Ashcroft FM. et al, (2017), Trends Endocrinol Metab, 28, 377 - 387

• Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes.

  Journal article

  Dahan T. et al, (2017), Diabetes, 66, 426 - 436

• Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.

  Journal article

  Brereton MF. et al, (2016), Nat Commun, 7

• Correction to 'Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels'.

  Journal article

  Proks P. et al, (2016), Philos Trans R Soc Lond B Biol Sci, 371