KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture
Journal article
Ashcroft FM., (2023), Diabetes, 72, 693 - 702
Glucokinase activity in diabetes: too much of a good thing?
Journal article
Ashcroft FM. et al, (2022), Trends Endocrinol Metab
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.
Journal article
Haythorne E. et al, (2022), Nat Commun, 13
The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel.
Journal article
Pipatpolkai T. et al, (2022), J Physiol
Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate.
Journal article
Koberstein JN. et al, (2022), Proc Natl Acad Sci U S A, 119
Dissection-independent production of Plasmodium sporozoites from whole mosquitoes.
Journal article
Blight J. et al, (2021), Life Sci Alliance, 4
The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.
Journal article
Sachse G. et al, (2021), Diabetes, 70, 1145 - 1156
Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time.
Journal article
Usher SG. et al, (2021), J Vis Exp
Metabolic regulation of insulin secretion in health and disease
Journal article
Haythorne E. and Ashcroft FM., (2021), Biochemist, 43, 4 - 8
Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease
Journal article
Pipatpolkai T. et al, (2020), Communications Chemistry, 3
New insights into KATP channel gene mutations and neonatal diabetes mellitus.
Journal article
Pipatpolkai T. et al, (2020), Nat Rev Endocrinol
Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry.
Journal article
Usher SG. et al, (2020), Elife, 9
Erratum. Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. Diabetes Care 2014;37:3333-3335
Journal article
Myngheer N. et al, (2019), Diabetes care, 42
Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo.
Journal article
Ved N. et al, (2019), Lab Anim
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.
Journal article
Haythorne E. et al, (2019), Nat Commun, 10
Correction to: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
Journal article
Cantley J. and Ashcroft FM., (2019), BMC Biol, 17
Correction: Systemic administration of glibenclamide fails to achieve therapeutic levels in the brain and cerebrospinal fluid of rodents (PLoS ONE (2015) 10: 7 (e0134476) DOI: 10.1371/journal.pone.0134476)
Journal article
Lahmann C. et al, (2019), PLoS ONE, 14
Hyperglycaemia adversely affects mitochondrial function in pancreatic islets
Conference paper
Haythorne E. et al, (2019), DIABETIC MEDICINE, 36, 37 - 37
Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding.
Journal article
Puljung M. et al, (2019), Elife, 8