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Publications

Glucokinase activity in diabetes: too much of a good thing?

Ashcroft FM. et al, (2022), Trends Endocrinol Metab

Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.

Haythorne E. et al, (2022), Nat Commun, 13

The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel.

Pipatpolkai T. et al, (2022), J Physiol

Dissection-independent production of Plasmodium sporozoites from whole mosquitoes.

Blight J. et al, (2021), Life Sci Alliance, 4

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.

Sachse G. et al, (2021), Diabetes, 70, 1145 - 1156

Voices: Insulin and beyond

Roth J. et al, (2021), Cell Metabolism, 33, 692 - 699

Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time.

Usher SG. et al, (2021), J Vis Exp

Metabolic regulation of insulin secretion in health and disease

Haythorne E. and Ashcroft FM., (2021), Biochemist, 43, 4 - 8

Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease

Pipatpolkai T. et al, (2020), Communications Chemistry, 3

New insights into KATP channel gene mutations and neonatal diabetes mellitus.

Pipatpolkai T. et al, (2020), Nat Rev Endocrinol

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry.

Usher SG. et al, (2020), Elife, 9

Erratum. Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. Diabetes Care 2014;37:3333-3335

Myngheer N. et al, (2019), Diabetes care, 42

Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo.

Ved N. et al, (2019), Lab Anim

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.

Haythorne E. et al, (2019), Nat Commun, 10

Correction to: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

Cantley J. and Ashcroft FM., (2019), BMC Biol, 17

Correction: Systemic administration of glibenclamide fails to achieve therapeutic levels in the brain and cerebrospinal fluid of rodents (PLoS ONE (2015) 10: 7 (e0134476) DOI: 10.1371/journal.pone.0134476)

Lahmann C. et al, (2019), PLoS ONE, 14

Hyperglycaemia adversely affects mitochondrial function in pancreatic islets

Haythorne E. et al, (2019), DIABETIC MEDICINE, 36, 37 - 37

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding.

Puljung M. et al, (2019), Elife, 8

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Vergari E. et al, (2019), Nat Commun, 10

Low extracellular magnesium does not impair glucose-stimulated insulin secretion.

Gommers LMM. et al, (2019), PLoS One, 14

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