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What is fMRI?
Take a journey around the brain with Ossie from Oxford Sparks. Find out more and read about the science behind the animation at www.oxfordsparks.net/mri
My PhD thesis
- Ultra High-Field MRI Physics Research Group
- Director of Operations, Wellcome Centre for Integrative Neuroimaging
Developing methods for Ultra High Field MRI
The last twenty years have seen a huge leap forward in our understanding of how the human brain works, and forefront in the technologies that have enabled this is the technique of functional Magnetic Resonance Imaging (fMRI). My research program involves pushing the technological boundaries of the MRI technique to reveal new insights about how the brain functions normally, and how it is affected by disease.
In 2011 the FMRIB Centre installed a state-of-the-art MRI scanner operating at a magnetic field strength of 7 Tesla. This is over 5 times stronger than a standard clinical system and enables the structure and function of the brain to be studied in far higher detail than has previously been possible. I have responsibility for delivering the 7T project and coordinating research on the system.
As well as facilitating clinical and neuroscience research on the Centre's two MRI scanners and providing MR physics input into those research projects, I have a research interest in improving the quality of MRI images using a technique called 'dynamic shimming'.
I am heavily involved in communicating the research we do to the general public (for example, see the animation on the left) and have been working with schools to inspire the next generation of scientists. I am on the Department Athena-Swan Committee which aims to improve the workplace for all and promote women in science.
Delineating extrastriate visual area MT(V5) using cortical myeloarchitecture.
Bridge H. et al, (2014), Neuroimage, 93 Pt 2, 231 - 236
Requirements for room temperature shimming of the human brain.
Clare S. et al, (2006), Magn Reson Med, 55, 210 - 214
Methodological issues relating to in vivo cortical myelography using MRI.
Clare S. and Bridge H., (2005), Hum Brain Mapp, 26, 240 - 250
Single-shot T2(*) measurement to establish optimum echo time for fMRI: studies of the visual, motor, and auditory cortices at 3.0 T.
Clare S. et al, (2001), Magn Reson Med, 45, 930 - 933
Investigating the Stability of Fine-Grain Digit Somatotopy in Individual Human Participants.
Kolasinski J. et al, (2016), J Neurosci, 36, 1113 - 1127
Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation.
Goksan S. et al, (2017), Magn Reson Med, 78, 625 - 631
Ultra-High-Field fMRI Reveals a Role for the Subiculum in Scene Perceptual Discrimination.
Hodgetts CJ. et al, (2017), J Neurosci, 37, 3150 - 3159
Increasing lateralized motor activity in younger and older adults using Real-time fMRI during executed movements.
Neyedli HF. et al, (2017), Neuroscience
Perceptually relevant remapping of human somatotopy in 24 hours.
Kolasinski J. et al, (2016), Elife, 5
Individual Differences in the Alignment of Structural and Functional Markers of the V5/MT Complex in Primates.
Large I. et al, (2016), Cereb Cortex, 26, 3928 - 3944