Contact information

Email	stephen.goodwin@dpag.ox.ac.uk
Tel	01865 272454

My connections

Group Leader Centre for Neural Circuits and Behaviour
Wellcome Trust Wellcome Trust Senior Investigator
Magdalen College College
Goodwin Group Research Group

Stephen Goodwin

BSc, MA, PhD

Professor of Neurogenetics

Biography

Genetic dissection of Sexual BehaviouR

Stephen studied genetics as an undergraduate at the University of Glasgow, and researched Drosophila learning and memory for his Ph.D. After a postdoctoral stint in Jeff Hall’s lab at Brandeis University (USA), where he used molecular-genetic and behavioural approaches in the fruit fly to understand how the sexual identity of a nervous system and its behaviours are specified, he returned to the UK and spent 10 years leading a research group at the University of Glasgow. He arrived in Oxford in 2009, where he is a Professor of Neurogenetics, a Wellcome Trust Senior Investigator, and a Tutorial Fellow in Genetics at Magdalen College. He is part of the Centre for Neural Circuits and Behaviour along with the groups of Gero Miesenböck, Martin Booth, Scott Waddell, Korneel Hens and Tim Vogels.

Stephen’s group uses the fruit fly, Drosophila melanogaster, to study the genetic, developmental, and neural mechanisms that underlie sex-specific behaviours in higher animals. In particular, the elaborate courtship ritual performed by the male fly has provided remarkable insights into how the neural circuitry underlying sexual behaviour, which is largely innate in flies, is built into the nervous system during development, and how this circuitry functions in the adult. The fly has the advantages of advanced molecular genetics approaches along with well-defined anatomy and physiology.

Sperm and sex peptide stimulate aggression in female Drosophila.
Bath E. et al, (2017), Nat Ecol Evol, 1
Neural circuitry coordinating male copulation.
Pavlou HJ. et al, (2016), Elife, 5
Neural circuitry coordinating male copulation
Pavlou HJ. et al, (2016), eLife, 5
Activation of Latent Courtship Circuitry in the Brain of Drosophila Females Induces Male-like Behaviors.
Rezával C. et al, (2016), Curr Biol, 26, 2508 - 2515
Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.
Clough E. et al, (2014), Dev Cell, 31, 761 - 773
Stephen F. Goodwin.
Goodwin SF., (2014), Curr Biol, 24, R720 - R722
Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior.
Nojima T. et al, (2014), Fly (Austin), 8
Sexually dimorphic octopaminergic neurons modulate female postmating behaviors in Drosophila.
Rezával C. et al, (2014), Curr Biol, 24, 725 - 730
Sexually dimorphic octopaminergic neurons modulate female postmating behaviors in drosophila
Rezával C. et al, (2014), Current Biology, 24, 725 - 730
Aggression: tachykinin is all the rage.
Pavlou HJ. et al, (2014), Curr Biol, 24, R243 - R244
The evolution of novelty in conserved genes; Evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons
Parker DJ. et al, (2014), Heredity, 112, 300 - 306
The evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons.
Parker DJ. et al, (2014), Heredity (Edinb), 112, 300 - 306
Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system.
Neville MC. et al, (2014), Curr Biol, 24, 229 - 241
Sex-specific responses to sexual familiarity, and the role of olfaction in Drosophila: a new analysis confirms original results.
Tan CK. et al, (2014), Proc Biol Sci, 281
Sex-specific responses to sexual familiarity, and the role of olfaction in Drosophila.
Tan CK. et al, (2013), Proc Biol Sci, 280
Sex-specific responses to sexual familiarity, and the role of olfaction in Drosophila
Tan CKW. et al, (2013), Proceedings of the Royal Society B: Biological Sciences, 280
Courtship behavior in Drosophila melanogaster: towards a 'courtship connectome'.
Pavlou HJ. and Goodwin SF., (2013), Curr Opin Neurobiol, 23, 76 - 83
Genetic control of courtship behavior in the housefly: evidence for a conserved bifurcation of the sex-determining pathway.
Meier N. et al, (2013), PLoS One, 8
Mapping female post-mating behaviours in the fruit fly's nervous system
Rezaval C. et al, (2012), JOURNAL OF NEUROGENETICS, 26, 53 - 53
Substrate-borne vibratory communication during courtship in Drosophila melanogaster.
Fabre CC. et al, (2012), Curr Biol, 22, 2180 - 2185
The best laid plans: analyzing courtship defects in Drosophila.
Goodwin SF. and O'Dell KM., (2012), Cold Spring Harb Protoc, 2012, 1140 - 1145
Genome-wide approaches to understanding behaviour in Drosophila melanogaster.
Neville M. and Goodwin SF., (2012), Brief Funct Genomics, 11, 395 - 404
Neural circuitry underlying Drosophila female postmating behavioral responses.
Rezával C. et al, (2012), Curr Biol, 22, 1155 - 1165
Neural circuitry underlying Drosophila female postmating behavioral responses
Rezával C. et al, (2012), Current Biology, 22, 1155 - 1165
Invertebrate neuroethology: food play and sex.
Rezával C. et al, (2011), Curr Biol, 21, R960 - R962
Advances in Genetics
Friedman T. et al, (2011)
Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster.
Rideout EJ. et al, (2010), Nat Neurosci, 13, 458 - 466
Genetic dissection of neural circuits & behaviour
Goodwin SF., (2009), 65
Sexual dimorphism: can you smell the difference?
Rideout EJ. and Goodwin SF., (2008), Curr Biol, 18, R425 - R427
Fly courtship song: triggering the light fantastic.
Dornan AJ. and Goodwin SF., (2008), Cell, 133, 210 - 212
Compartmentalization of neuronal and peripheral serotonin synthesis in Drosophila melanogaster.
Neckameyer WS. et al, (2007), Genes Brain Behav, 6, 756 - 769
The sex-determination genes fruitless and doublesex specify a neural substrate required for courtship song.
Rideout EJ. et al, (2007), Curr Biol, 17, 1473 - 1478
The neuropeptide SIFamide modulates sexual behavior in Drosophila.
Terhzaz S. et al, (2007), Biochem Biophys Res Commun, 352, 305 - 310
Control of male sexual behavior in Drosophila by the sex determination pathway.
Billeter JC. et al, (2006), Curr Biol, 16, R766 - R776
Isoform-specific control of male neuronal differentiation and behavior in Drosophila by the fruitless gene.
Billeter JC. et al, (2006), Curr Biol, 16, 1063 - 1076
Functional conservation of the fruitless male sex-determination gene across 250 Myr of insect evolution.
Gailey DA. et al, (2006), Mol Biol Evol, 23, 633 - 643
Female receptivity phenotype of icebox mutants caused by a mutation in the L1-type cell adhesion molecule neuroglian.
Carhan A. et al, (2005), Genes Brain Behav, 4, 449 - 465
GAL4 enhancer trap targeting of the Drosophila sex determination gene fruitless.
Dornan AJ. et al, (2005), Genesis, 42, 236 - 246
Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster.
Sharma P. et al, (2005), J Neurogenet, 19, 57 - 85
Characterization of Drosophila fruitless-gal4 transgenes reveals expression in male-specific fruitless neurons and innervation of male reproductive structures.
Billeter JC. and Goodwin SF., (2004), J Comp Neurol, 475, 270 - 287
The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila.
Song HJ. et al, (2002), Genetics, 162, 1703 - 1724
3 Genes mediating sex-specific behaviors in Drosophila
Billeter JC. et al, (2002), Advances in Genetics, 47, 87 - 116
Genes mediating sex-specific behaviors in Drosophila.
Billeter JC. et al, (2002), Adv Genet, 47, 87 - 116
Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless.
Anand A. et al, (2001), Genetics, 158, 1569 - 1595
Spatial, temporal, and sexually dimorphic expression patterns of the fruitless gene in the Drosophila central nervous system.
Lee G. et al, (2000), J Neurobiol, 43, 404 - 426
Aberrant splicing and altered spatial expression patterns in fruitless mutants of Drosophila melanogaster.
Goodwin SF. et al, (2000), Genetics, 154, 725 - 745
Molecular neurogenetics of sexual differentiation and behaviour.
Goodwin SF., (1999), Curr Opin Neurobiol, 9, 759 - 765
Abnormal courtship conditioning in males mutant for the RI regulatory subunit of Drosophila protein kinase A.
O'Dell KM. et al, (1999), J Neurogenet, 13, 105 - 118
Defective learning in mutants of the Drosophila gene for a regulatory subunit of cAMP-dependent protein kinase.
Goodwin SF. et al, (1997), J Neurosci, 17, 8817 - 8827
Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene.
Ryner LC. et al, (1996), Cell, 87, 1079 - 1089
Analysis and inactivation of vha55, the gene encoding the vacuolar ATPase B-subunit in Drosophila melanogaster reveals a larval lethal phenotype.
Davies SA. et al, (1996), J Biol Chem, 271, 30677 - 30684
Evidence that the 16 kDa proteolipid (subunit c) of the vacuolar H(+)-ATPase and ductin from gap junctions are the same polypeptide in Drosophila and Manduca: molecular cloning of the Vha16k gene from Drosophila.
Finbow ME. et al, (1994), J Cell Sci, 107 ( Pt 7), 1817 - 1824
Reverse genetics of Drosophila brain structure and function.
Sentry JW. et al, (1994), Prog Neurobiol, 42, 299 - 308
REVERSE GENETICS OF NERVOUS-SYSTEM SIGNAL TRANSDUCTION IN DROSOPHILA
KAISER K. et al, (1993), JOURNAL OF CELLULAR BIOCHEMISTRY, 258 - 258
Analysis of the gene encoding a 16-kDa proteolipid subunit of the vacuolar H(+)-ATPase from Manduca sexta midgut and tubules.
Dow JA. et al, (1992), Gene, 122, 355 - 360
"Site-selected" transposon mutagenesis of Drosophila.
Kaiser K. and Goodwin SF., (1990), Proc Natl Acad Sci U S A, 87, 1686 - 1690

Key Publications

Sperm and sex peptide stimulate aggression in female Drosophila.
Bath E. et al, (2017), Nat Ecol Evol, 1
Neural circuitry coordinating male copulation.
Pavlou HJ. et al, (2016), Elife, 5
Activation of Latent Courtship Circuitry in the Brain of Drosophila Females Induces Male-like Behaviors.
Rezával C. et al, (2016), Curr Biol, 26, 2508 - 2515
Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.
Clough E. et al, (2014), Dev Cell, 31, 761 - 773
Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system.
Neville MC. et al, (2014), Curr Biol, 24, 229 - 241

Recent Publications

Sperm and sex peptide stimulate aggression in female Drosophila.
Bath E. et al, (2017), Nat Ecol Evol, 1
Neural circuitry coordinating male copulation.
Pavlou HJ. et al, (2016), Elife, 5
Neural circuitry coordinating male copulation
Pavlou HJ. et al, (2016), eLife, 5
Activation of Latent Courtship Circuitry in the Brain of Drosophila Females Induces Male-like Behaviors.
Rezával C. et al, (2016), Curr Biol, 26, 2508 - 2515
Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.
Clough E. et al, (2014), Dev Cell, 31, 761 - 773

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