Sarosh Irani

• LGI1-antibody encephalitis is characterised by frequent, multifocal clinical and subclinical seizures.

  Aurangzeb S. et al, (2017), Seizure, 50, 14 - 17

• Autoantibody-mediated diseases of the CNS: Structure, dysfunction and therapy.

  Varley J. et al, (2017), Neuropharmacology

• Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies.

  Lang B. et al, (2017), J Neurol Neurosurg Psychiatry, 88, 353 - 361

• Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis.

  Miller TD. et al, (2017), Brain

• G2A1B3AA receptor antibodies and their clinical associations.

  Waters PJ. and Irani SR., (2017), Neurology, 88, 1010 - 1011

• The trouble with plasma cells: Getting to the root cause.

  Rüegg S. and Irani SR., (2017), Neurology, 88, 340 - 341

• Antibody-associated epilepsies: Clinical features, evidence for immunotherapies and future research questions.

  Bakpa OD. et al, (2016), Seizure, 41, 26 - 41

• Multiple sequential antibody-associated syndromes with a recurrent mutated neuroblastoma.

  Amini A. et al, (2016), Neurology, 87, 634 - 636

• Acute variegate porphyria presenting with reversible cerebral vasoconstriction.

  Webb AJ. et al, (2016), Clin Neurol Neurosurg, 146, 102 - 104

• Neurexin-3α: A new antibody target in autoimmune encephalitis.

  Waters PJ. and Irani SR., (2016), Neurology, 86, 2222 - 2223

• Tocilizumab-associated multifocal cerebral thrombotic microangiopathy.

  Jewell P. et al, (2016), Neurol Clin Pract, 6, e24 - e26

• Autoantibodies to central nervous system neuronal surface antigens: psychiatric symptoms and psychopharmacological implications.

  Pollak TA. et al, (2016), Psychopharmacology (Berl), 233, 1605 - 1621

• A clinical approach to diagnosis of autoimmune encephalitis.

  Graus F. et al, (2016), Lancet Neurol, 15, 391 - 404

• Creutzfeldt-Jakob Disease-Like Periodic Sharp Wave Complexes in Voltage-Gated Potassium Channel-Complex Antibodies Encephalitis: A Case Report.

  Savard M. et al, (2016), J Clin Neurophysiol, 33, e1 - e4

• 'Moonlighting' surface antigens: a paradigm for autoantibody pathogenicity in neurology?

  Irani SR., (2016), Brain, 139, 304 - 306

• Voltage-gated potassium channel-complex autoimmunity and associated clinical syndromes.

  Irani SR. and Vincent A., (2016), Handb Clin Neurol, 133, 185 - 197

• Treating seizures and preventing amnesia in LGI1-antibody encephalitis: A new MRI signature?

  Varley JA. and Irani SR., (2015), Neurol Neuroimmunol Neuroinflamm, 2

• Targeting the Interleukin 6 Receptor to Treat Neuromyelitis Optica.

  Irani SR. and Vincent A., (2015), JAMA Neurol, 72, 747 - 748

• Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization.

  Pettingill P. et al, (2015), Neurology, 84, 1233 - 1241

• The active intrathecal B-cell response in LGI1-antibody encephalitis.

  Irani SR. et al, (2015), Lancet, 385 Suppl 1

• Clinical and experimental studies of potentially pathogenic brain-directed autoantibodies: current knowledge and future directions.

  Varley J. et al, (2015), J Neurol, 262, 1081 - 1095

• Cell-surface neuronal antibodies in patients with Japanese encephalitis virus

  Nibber A. et al, (2014), JOURNAL OF NEUROIMMUNOLOGY, 275, 6 - 7

• More than memory impairment in voltage-gated potassium channel complex encephalopathy.

  Bettcher BM. et al, (2014), Eur J Neurol, 21, 1301 - 1310

• Episodic bradycardia as neurocardiac prodrome to voltage-gated potassium channel complex/leucine-rich, glioma inactivated 1 antibody encephalitis.

  Naasan G. et al, (2014), JAMA Neurol, 71, 1300 - 1304

• Cell-surface central nervous system autoantibodies: clinical relevance and emerging paradigms.

  Irani SR. et al, (2014), Ann Neurol, 76, 168 - 184

• Effect of rituximab in patients with leucine-rich, glioma-inactivated 1 antibody-associated encephalopathy.

  Irani SR. et al, (2014), JAMA Neurol, 71, 896 - 900

• NMDA receptor antibodies associated with distinct white matter syndromes.

  Hacohen Y. et al, (2014), Neurol Neuroimmunol Neuroinflamm, 1

• Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype.

  Irani SR. et al, (2013), Brain, 136, 3151 - 3162

• Long-term clinical course with voltage-gated potassium channel antibody in Morvan's syndrome.

  Kim NH. et al, (2013), J Neurol, 260, 2407 - 2408

• Organic neuropsychiatry: a treatable cause of suicidal behaviour.

  Irani SR. et al, (2013), Pract Neurol, 13, 44 - 48

• RE-THINKING THE ROLE OF THE HUMAN HIPPOCAMPUS IN RETROGRADE EPISODIC MEMORY

  Miller TD. et al, (2013), JOURNAL OF COGNITIVE NEUROSCIENCE, 169 - 169

• Opsoclonus myoclonus syndrome associated with GQ1b antibodies.

  Morales-Briceño H. et al, (2012), Mov Disord, 27, 1615 - 1616

• Acute onset of focal seizures, psychiatric features and confusion: a case of autoimmune encephalitis?

  Al-Diwani A. et al, (2012), BMJ Case Rep, 2012

• What should you know about limbic encephalitis?

  Machado S. et al, (2012), Arq Neuropsiquiatr, 70, 817 - 822

• "Autoantibodies in epilepsies" in Borderland of Epilepsy Revisited

  Reuber M. and Schachter SC., (2012)

• NMDA receptor autoantibodies in sporadic Creutzfeldt-Jakob disease.

  Mackay G. et al, (2012), J Neurol, 259, 1979 - 1981

• NMDA receptor antibody related encephalitis

  Irani SR., (2012), EUROPEAN JOURNAL OF NEUROLOGY, 19, 817 - 817

• Morvan syndrome: clinical and serological observations in 29 cases.

  Irani SR. et al, (2012), Ann Neurol, 72, 241 - 255

• Immunotherapy-responsive chorea as the presenting feature of LGI1-antibody encephalitis.

  Tofaris GK. et al, (2012), Neurology, 79, 195 - 196

• Republished review: Autoantibody testing in encephalopathies.

  Lee R. et al, (2012), Postgrad Med J, 88, 280 - 289

• The expanding spectrum of clinically-distinctive, immunotherapy-responsive autoimmune encephalopathies.

  Irani SR. and Vincent A., (2012), Arq Neuropsiquiatr, 70, 300 - 304

• THE UTILITY OF SOX ANTIBODIES FOR CANCER PREDICTION IN PATIENTS WITH PARANEOPLASTIC NEUROLOGICAL DISORDERS

  Maddison P. et al, (2012), JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 83

• Case 34-2011: a man with memory loss and partial seizures.

  Irani SR. et al, (2012), N Engl J Med, 366, 768 - 769

• Autoantibody testing in encephalopathies.

  Lee R. et al, (2012), Pract Neurol, 12, 4 - 13

• Tonic seizures: a diagnostic clue of anti-LGI1 encephalitis?

  Irani SR. et al, (2011), Neurology, 77, 2140 - 2141

• Potentially pathogenic autoantibodies associated with epilepsy and encephalitis in children and adults.

  Vincent A. et al, (2011), Epilepsia, 52 Suppl 8, 8 - 11

• MORVAN'S SYNDROME: CLINICAL AND SEROLOGICAL FINDINGS IN 27 CASES

  Irani SR. et al, (2011), EUROPEAN JOURNAL OF NEUROLOGY, 18, 652 - 652

• Progressive encephalomyelitis with rigidity and myoclonus: glycine and NMDA receptor antibodies.

  Turner MR. et al, (2011), Neurology, 77, 439 - 443

• Autoantibodies associated with diseases of the CNS: new developments and future challenges.

  Vincent A. et al, (2011), Lancet Neurol, 10, 759 - 772

• Faciobrachial Dystonic Attacks: Seizures or Movement Disorder? Reply

  Irani SR. et al, (2011), ANNALS OF NEUROLOGY, 70, 180 - 180

• NMDA receptor antibody encephalitis.

  Irani SR. and Vincent A., (2011), Curr Neurol Neurosci Rep, 11, 298 - 304

• Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis.

  Irani SR. et al, (2011), Ann Neurol, 69, 892 - 900

• Autoimmune encephalitis -- new awareness, challenging questions.

  Irani SR. and Vincent A., (2011), Discov Med, 11, 449 - 458

• Autoimmune encephalitis.

  Irani SR. et al, (2011), BMJ, 342

• Disease-relevant autoantibodies in first episode schizophrenia.

  Zandi MS. et al, (2011), J Neurol, 258, 686 - 688

• Autoimmune epilepsies.

  Irani SR. et al, (2011), Curr Opin Neurol, 24, 146 - 153

• FDG-PET hyperactivity in basal ganglia correlating with clinical course in anti-NDMA-R antibodies encephalitis.

  Maeder-Ingvar M. et al, (2011), J Neurol Neurosurg Psychiatry, 82, 235 - 236

• Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study.

  Granerod J. et al, (2010), Lancet Infect Dis, 10, 835 - 844

• Caspr2 antibodies in patients with thymomas.

  Vincent A. and Irani SR., (2010), J Thorac Oncol, 5, S277 - S280

• Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia.

  Irani SR. et al, (2010), Brain, 133, 2734 - 2748

• N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes.

  Irani SR. et al, (2010), Brain, 133, 1655 - 1667

• The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins.

  Vincent A. et al, (2010), Curr Opin Neurol, 23, 144 - 150

• Anti-N-methyl-D-aspartate-receptor encephalitis in a four-year-old girl.

  Biancheri R. et al, (2010), J Pediatr, 156, 332 - 334

• Anti-N-methyl-D-aspartate receptor antibodies: a potentially treatable cause of encephalitis in the intensive care unit.

  Davies G. et al, (2010), Crit Care Med, 38, 679 - 682

• Limbic encephalitis associated with antibodies to the NMDA receptor in Hodgkin lymphoma.

  Zandi MS. et al, (2009), Neurology, 73, 2039 - 2040

• Immunotherapy: responsive autoimmune encephalopathy associated with bullous pemphigoid.

  Soni A. et al, (2009), J Neurol Neurosurg Psychiatry, 80, 1412 - 1413

• N-methyl-D-aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica.

  Dale RC. et al, (2009), Ann Neurol, 66, 704 - 709

• EARLY AND CONTINUED TREATMENT OF N-METHYL D-ASPARTATE RECEPTOR-ANTIBODY ENCEPHALITIS OPTIMISES OUTCOME OF A PREDOMINANTLY NON-PARANEOPLASTIC DISEASE

  Irani SR. et al, (2009), JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 80

• CROSSING INTO ORGANIC NEUROPSYCHIATRY?

  Irani SR. et al, (2009), JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 80

• Anti-NMDA receptor encephalitis: a video case report.

  Labate A. et al, (2009), Epileptic Disord, 11, 267 - 269

• IMMUNOTHERAPY-RESPONSIVE AUTOIMMUNE ENCEPHALOPATHY ASSOCIATED WITH BULLOUS PEMPHIGOID

  Soni A. et al, (2009), RHEUMATOLOGY, 48, I120 - I121

• CLINICAL FEATURES AND FOLLOW-UP OF 13 PATIENTS WITH ANTIBODIES AGAINST NMDA RECEPTORS

  Irani SR. et al, (2009), JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 80, 452 - 452

• Immunotherapy-responsive seizure-like episodes with potassium channel antibodies.

  Irani SR. et al, (2008), Neurology, 71, 1647 - 1648

• A novel antigenic target in Morvan's syndrome

  Irani SR. et al, (2008), JOURNAL OF NEUROIMMUNOLOGY, 203, 181 - 181

• Hypothermia in VGKC antibody-associated limbic encephalitis.

  Jacob S. et al, (2008), J Neurol Neurosurg Psychiatry, 79, 202 - 204

• Pure autonomic failure followed by amyotrophy.

  Irani SR. et al, (2007), Neurology, 68, 792 - 793

• Limbic encephalitis: under-recognition of voltage-gated potassium channel antibodies.

  Irani SR. et al, (2007), Eur Neurol, 58

• Early intervention in acute renal failure: evidence of inadequate intravenous fluid treatment in UK hospitals.

  Matheson NJ. et al, (2006), BMJ, 333

• Doctor's knowledge of driving regulations: an interview-based survey.

  Irani SR. et al, (2006), Clin Med (Lond), 6, 217 - 219

• A novel neurological mechanism to explain the adverse effect of depression on coronary artery disease.

  Irani SR., (2005), Med Hypotheses, 64, 284 - 287

• The validity and reliability of 6 sets of clinical criteria to classify Alzheimer's disease and vascular dementia in cases confirmed post-mortem: added value of a decision tree approach.

  Hogervorst E. et al, (2003), Dement Geriatr Cogn Disord, 16, 170 - 180

• Psychological heart disease?

  Irani SR., (2001), Arch Intern Med, 161, 485 - 486

• Stimulus attributes influencing motion integration in the human visual system

  Irani SR. and Benson PJ., (2000), EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 72 - 72

Recent Publications

• LGI1-antibody encephalitis is characterised by frequent, multifocal clinical and subclinical seizures.

  Aurangzeb S. et al, (2017), Seizure, 50, 14 - 17

• Autoantibody-mediated diseases of the CNS: Structure, dysfunction and therapy.

  Varley J. et al, (2017), Neuropharmacology

• Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies.

  Lang B. et al, (2017), J Neurol Neurosurg Psychiatry, 88, 353 - 361

• Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis.

  Miller TD. et al, (2017), Brain

• G2A1B3AA receptor antibodies and their clinical associations.

  Waters PJ. and Irani SR., (2017), Neurology, 88, 1010 - 1011