Postdoctoral Research Fellow
Impaired autophagy plays a pathogenic role in several major neurodegenerative diseases and strategic interventions of the autophagic pathway are emerging as promising therapeutic targets. I am using imaging techniques and functional assays to delineate mechanisms of endosomal degradation and study their significance for neuronal viability.
The endosomal pathway in Parkinson's disease.
Perrett RM. et al, (2015), Mol Cell Neurosci, 66, 21 - 28
Pulsatile Hormonal Signaling to Extracellular Signal-regulated Kinase
Perrett RM. et al, (2014), Journal of Biological Chemistry, 289, 7873 - 7883
Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX.
Bigger BW. et al, (2006), Gene Ther, 13, 117 - 126