Sir Henry Wellcome Postdoctoral Fellow
I develop DTI methods with high spatial resolution. These would allow imaging of white matter fibres in difficult areas, for example where bundles are in close proximity of one another or when they enter grey matter.
One of the main difficulties of high-resolution imaging simply is time and if time is money, the currency of MRI experiments is SNR (signal-to-noise ratio). The better the SNR, the higher the quality of the data and the more reliable the result. SNR scales with the sampled volume and because high-resolution experiments aim to obtain signal from small pieces of tissue, SNR is reduced. This can be compensated by using longer measurement times thereby reducing the impact of noise. However, if we divide the brain up into smaller and smaller units, the absolute number of units to measure increases dramatically which means we already need more time to measure all of them.
My work focuses on tackling the SNR/time issue by developing accelerated acquisition methods that reduce scan times. I use FMRIB’s recently acquired 7 Tesla MRI scanner that is beneficial in two ways: the ultra-high magnetic field boosts the intrinsic SNR of experiments while it independently improves the performance of acceleration methods.
I am funded on a Sir Henry Wellcome postdoctoral fellowship to develop and apply my methods in the brain and spinal cord in the context of chronic pain and motor neuron disease (MND/ALS).
Two-dimensional-NGC-SENSE-GRAPPA for fast, ghosting-robust reconstruction of in-plane and slice-accelerated blipped-CAIPI echo planar imaging.
Koopmans PJ., (2017), Magn Reson Med, 77, 998 - 1009
High-resolution diffusion MRI at 7T using a three-dimensional multi-slab acquisition.
Wu W. et al, (2016), Neuroimage, 143, 1 - 14
Reducing slab boundary artifacts in three-dimensional multislab diffusion MRI using nonlinear inversion for slab profile encoding (NPEN).
Wu W. et al, (2016), Magn Reson Med, 76, 1183 - 1195
Large dynamic range relative B1+ mapping.
Padormo F. et al, (2016), Magn Reson Med, 76, 490 - 499
The relationship between oscillatory EEG activity and the laminar-specific BOLD signal.
Scheeringa R. et al, (2016), Proc Natl Acad Sci U S A, 113, 6761 - 6766