Research groups
Colleges
Liliana Minichiello
Professor of Cellular and Molecular Neuroscience
- Academic Research Leader
My primary long-standing research interest has been to define molecular and cellular mechanisms underlying synaptic plasticity, learning and memory.
Recent achievements and ongoing work in the lab involves elucidating how alteration of neurotrophin signalling and/or other molecules of interest in specific neurons affects the development of neural circuits and contribute to cognitive disorders, basal ganglia movement disorders, or to metabolic dysfunctions.
Lately, to break new ground in the understanding of neuronal function and associated pathologies, we have established single cell transcriptome analysis of adult neurons. This technology is particularly useful for the identification of molecular and functional heterogeneity within cell populations currently believed to be homogeneous.
I am also actively involved with teaching and examining activities of undergraduate (FHS Examiner) and postgraduate students at the University of Oxford. Established and managing DPhil and Postdoc internal seminar series for the Department of Pharmacology. I also contribute to administrative duties such as advisory committee, strategic direction and research committee meeting, teaching committee. And I am a member of AWERB Committee for Pharmacology and Biochemistry Departments, University of Oxford.
Recent publications
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Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunction.
Journal article
Malik MY. et al, (2024), Nat Metab
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Vascular smooth muscle cell-derived nerve growth factor regulates sympathetic collateral branching to innervate blood vessels in embryonic skin.
Journal article
Li W. et al, (2024), Biol Open, 13
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Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney.
Journal article
Gyarmati G. et al, (2024), J Clin Invest, 134
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A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange.
Journal article
Zhang K. et al, (2022), Dev Cell, 57, 1566 - 1581.e7
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NKCC1 Deficiency in Forming Hippocampal Circuits Triggers Neurodevelopmental Disorder: Role of BDNF-TrkB Signalling
Journal article
Szymanski J. and MINICHIELLO L., (2022)
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Heart neurons use clock genes to control myocyte proliferation.
Journal article
Tampakakis E. et al, (2021), Sci Adv, 7
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NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma.
Journal article
Lee S. et al, (2021), Nat Commun, 12
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A Neurotrophic Mechanism Directs Sensory Nerve Transit in Cranial Bone.
Journal article
Meyers CA. et al, (2020), Cell Rep, 31