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Staff Profile
University of Birmingham
John-Stuart Brittain
PhD
Academic Visitor
- Senior Lecturer, University of Birmingham
My personal website and publications list
My research involves the investigation of human motor control through transcranial electrical stimulation. My focus is on revealing the neural mechanisms underlying tremor, such as occur in Parkinson's disease and Essential Tremor, with a view to therapeutic treatment. I complement this cortical manipulation with the unique interventional opportunities afforded by deep brain stimulation to probe the subcortical contribution to these networks. By combining observational research with the manipulation of brain waves in patient cohorts and healthy volunteers I attempt to unveil the functional organisation and interaction of specific brain networks.
In 2015 John-Stuart was awarded a MRC New Investigator Research Grant, aimed at developing a non-invasive form of electrical stimulation as a realisable therapy for those afflicted with disabling tremors. The award will enable John-Stuart to pursue an independent research programme in the Nuffield Department of Clinical Neurosciences (Oxford University), while continuing his close collaboration with the MRC Brain Network Dynamics Unit to better understand the neurophysiology of tremor which informs viable treatment strategies.
I am privileged enough to enjoy active collaborations with a number of esteemed researchers, including David Halliday (Intelligent Systems Research Group, University of York), Kate Watkins (Speech and Brain Group, University of Oxford) and Marom Biksom (City College of New York).
Publications list (Scopus) (Google Scholar)
Teaching
Teaching resources are now available through the WebLearn portal
Research highlight
Recent publications
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The pedunculopontine region and breathing in Parkinson's disease.
Journal article
Hyam JA. et al, (2019), Ann Clin Transl Neurol, 6, 837 - 847
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Investigating and Modulating Physiological and Pathological Brain Oscillations: The Role of Oscillatory Activity in Neural Plasticity.
Journal article
Guerra A. et al, (2019), Neural Plast, 2019
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A functional micro-electrode mapping of ventral thalamus in essential tremor.
Journal article
Pedrosa DJ. et al, (2018), Brain, 141, 2644 - 2654
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Adaptive spectral tracking for coherence estimation: The z-tracker
Journal article
Halliday DM. et al, (2018), Journal of Neural Engineering, 15
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Directional local field potentials: A tool to optimize deep brain stimulation.
Journal article
Tinkhauser G. et al, (2018), Mov Disord, 33, 159 - 164
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The differentiated networks related to essential tremor onset and its amplitude modulation after alcohol intake.
Journal article
Pedrosa DJ. et al, (2017), Exp Neurol, 297, 50 - 61
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Modulation of Long-Range Connectivity Patterns via Frequency-Specific Stimulation of Human Cortex.
Journal article
Weinrich CA. et al, (2017), Curr Biol, 27, 3061 - 3068.e3
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Tremor stability index: a new tool for differential diagnosis in tremor syndromes.
Journal article
di Biase L. et al, (2017), Brain, 140, 1977 - 1986
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Guiding transcranial brain stimulation by EEG/MEG to interact with ongoing brain activity and associated functions: A position paper.
Journal article
Thut G. et al, (2017), Clin Neurophysiol, 128, 843 - 857
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Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks.
Journal article
Herz DM. et al, (2017), Elife, 6