Funding
Co-Investigator MRC Research Grant (2015-2019)
MRC New Investigator Research Grant Holder (present)
Research groups
Colleges
John Dawes
Principal investigator
- MRC New Investigator
- Retained Lecturer in Neurophysiology, Wadham College
Research Summary
It is now well established that the immune system contributes to pathological pain sates and one relatively under studied aspect of this is through the action of autoantibodies. Neuropathic pain is common in patients with autoantibodies directed against components of the voltage gated potassium channel complex such as CASPR2 and LGI1. By using patient samples in combination with basic pain research my aim is to better understand the mechanisms of autoantibody mediated pain and by doing so uncover novel molecular pathways regulating pain sensitivity as well as revealing clinically relevant targets for the development of future therapies.
Key publications
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Journal article
Dawes JM. et al, (2018), Neuron, 97, 806 - 822.e10
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Journal article
Dawes JM. and Vincent A., (2016), Curr Opin Support Palliat Care, 10, 137 - 142
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Journal article
Dawes JM. et al, (2011), Sci Transl Med, 3
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Journal article
Dawes JM. et al, (2014), PLoS One, 9
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Journal article
Calvo M. et al, (2012), Lancet Neurol, 11, 629 - 642
Recent publications
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Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity
Journal article
Carroll L. et al, (2020), The Neuroscientist: reviews at the interface of basic and clinical neurosciences
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Journal article
Baskozos G. et al, (2019), Pain, 160, 463 - 485
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Journal article
Dawes JM. et al, (2018), Neuron, 97, 806 - 822.e10
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Journal article
Lunn TH. et al, (2018), Eur J Pain, 22, 170 - 180
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Journal article
Sleigh JN. et al, (2017), Proc Natl Acad Sci U S A, 114, E3324 - E3333