Funding
Co-Investigator MRC Research Grant (2015-2019)
MRC New Investigator Research Grant Holder (present)
Research groups
Colleges
John Dawes
Associate Professor
- MRC New Investigator
- Retained Lecturer in Neurophysiology, Wadham College
Research Summary
It is now well established that the immune system contributes to pathological pain sates and one relatively under studied aspect of this is through the action of autoantibodies. Neuropathic pain is common in patients with autoantibodies directed against components of the voltage gated potassium channel complex such as CASPR2 and LGI1. By using patient samples in combination with basic pain research my aim is to better understand the mechanisms of autoantibody mediated pain and by doing so uncover novel molecular pathways regulating pain sensitivity as well as revealing clinically relevant targets for the development of future therapies.
Key publications
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Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability.
Journal article
Dawes JM. et al, (2018), Neuron, 97, 806 - 822.e10
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Autoantibodies and pain.
Journal article
Dawes JM. and Vincent A., (2016), Curr Opin Support Palliat Care, 10, 137 - 142
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CXCL5 mediates UVB irradiation-induced pain.
Journal article
Dawes JM. et al, (2011), Sci Transl Med, 3
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The role of the immune system in the generation of neuropathic pain.
Journal article
Calvo M. et al, (2012), Lancet Neurol, 11, 629 - 642
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Autoantibodies and neuropathic pain
Chapter
Dawes JM. and Bennett DL., (2018), The Oxford Handbook of the Neurobiology of Pain, 833 - 850
Recent publications
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A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity.
Journal article
Farah A. et al, (2024), Brain
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Antibody-mediated autoimmunity in symptom-based disorders: position statement and proceedings from an international workshop.
Journal article
Mountford R. et al, (2024), Pain Rep, 9
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Corrigendum: A role for pathogenic autoantibodies in small fiber neuropathy?
Journal article
Daifallah O. et al, (2023), Front Mol Neurosci, 16
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Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological Comparisons.
Journal article
Ramanathan S. et al, (2021), Ann Neurol, 90, 683 - 690
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The structure of sensory afferent compartments in health and disease
Journal article
Middleton SJ. et al, (2021), Journal of Anatomy