Research groups
Ira Milosevic
John Black Senior Research Fellow in Parkinson’s disease
Ira studied Molecular Biology at the University of Zagreb, Croatia, and undertook her MSc and PhD studies in Germany at the Georg-August University and International Max Planck Research School (IMPRS) in Neuroscience as a Boehringer Ingelheim Fonds Scholar. She held the EMBO Long-Term Fellowship and Epilepsy Foundation Fellowship during her postdoctoral training with Pietro De Camilli at the Yale University School of Medicine in New Haven, CT. In 2013, Ira was awarded a prestigious Emmy Noether Young Investigator grant from the German Research Council to establish her own research programme at the European Neuroscience Institute - A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society, focusing on the molecular underpinnings of synaptic transmission.
Ira joined the Wellcome Centre for Human Genetics and Nuffield Department of Medicine at the University of Oxford as Associate Professor and Group Head in 2020
Recent publications
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Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling.
Preprint
Domingues N. et al, (2024)
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Upregulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain.
Journal article
Agostini F. et al, (2024), J Biol Chem, 300
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Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain.
Journal article
Agostini F. et al, (2024), bioRxiv
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Lack of peroxisomal catalase affects heat shock response in Caenorhabditis elegans.
Journal article
Musa M. et al, (2023), Life Sci Alliance, 6
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Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3.
Journal article
Upmanyu N. et al, (2022), Neuron