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FMRIB Physics Group

Microstructural Imaging

Diffusion Aquisition

I develop methods for post-mortem imaging of brains. These techniques aim to enable (a) very high-resolution MRI scans for delineation of fine anatomical features and (b) comparison against histological gold standards. Two major funded projects are underway to make use of these methods. The first aims to understand the neuropathological correlates of quantitative MRI signals (including diffusion and relaxography) in motor neuron disease, funded by the Medical Research Council. The second aims to use post-mortem diffusion imaging to enable white matter tractography in the developing human brain as part of the Developing Human Connectome Project, funded by the European Research Council. We are also exploring the potential for these methods to enable cross-species comparative anatomy and to be used in combination with polarized light imaging.