Postdoctoral MRI Physicist
I develop methods for post-mortem imaging of brains. These techniques aim to enable (a) very high-resolution MRI scans for delineation of fine anatomical features and (b) comparison against histological gold standards. Two major funded projects are underway to make use of these methods. The first aims to understand the neuropathological correlates of quantitative MRI signals (including diffusion and relaxography) in motor neuron disease, funded by the Medical Research Council. The second aims to use post-mortem diffusion imaging to enable white matter tractography in the developing human brain as part of the Developing Human Connectome Project, funded by the European Research Council. We are also exploring the potential for these methods to enable cross-species comparative anatomy and to be used in combination with polarized light imaging.
3D high spectral and spatial resolution imaging of ex vivo mouse brain.
Foxley S. et al, (2015), Med Phys, 42, 1463 - 1472
Improving diffusion-weighted imaging of post-mortem human brains: SSFP at 7 T.
Foxley S. et al, (2014), Neuroimage, 102 Pt 2, 579 - 589
Motor skill learning induces changes in white matter microstructure and myelination.
Sampaio-Baptista C. et al, (2013), J Neurosci, 33, 19499 - 19503
Detecting microstructural properties of white matter based on compartmentalization of magnetic susceptibility.
Chen WC. et al, (2013), Neuroimage, 70, 1 - 9
Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus.
Foxley S. et al, (2013), Brain Res, 1504, 85 - 96