Research groups
Colleges
Daniel C Anthony
Professor of Experimental Neuropathology
- Fellow of Somerville College
- Honorary Professor, University of Southern Denmark
The focus of the work of my lab is to identify how inflammation contributes to the outcome of acute and chronic brain injury or infection and the identification of novel biomarkers to diagnosis disease and predict progression. We are particularly interested in the role played by circulating extracellular vesicles in the pathogenesis of CNS disease and the way in which their presence impacts on behaviour.
I have published extensively on the neurobiology of inflammation with the help of creative friends and colleagues in Oxford and throughout the world. The lab is well equipped for in vivo biology, molecular biology, immunohistochemistry and metabolomics.
Following the completion of my PhD in 1994 at UCL, I joined Professor Hugh Perry, then in Oxford, on a British Biotech Fellowship investigating metalloproteinase expression in the CNS. It was during this period that I became interested in the leukocyte-mediated mechanisms of neurodegeneration. In 1998, I moved to a faculty position at the University of Southampton, where I was a Lecturer in Neurobiology before returning to Oxford in 2004. I am also a Fellow of Somerville College and hold an honorary Professorial position at the University of Southern Denmark.
Recent publications
-
Assessing the effect of anesthetic gas mixtures on hyperpolarized 13 C pyruvate metabolism in the rat brain.
Journal article
Healicon R. et al, (2022), Magn Reson Med
-
Correction to: SPIKE-1: A Randomised Phase II/III trial in a community setting, assessing use of camostat in reducing the clinical progression of COVID-19 by blocking SARS-CoV-2 Spike protein-initiated membrane fusion.
Journal article
Halford S. et al, (2022), Trials, 23
-
Reductive site-selective atypical C,Z-type/N2-C2 cleavage allows C-terminal protein amidation.
Journal article
Mollner TA. et al, (2022), Sci Adv, 8
-
Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes.
Journal article
Svirin E. et al, (2022), Cells, 11
-
Modifying the maternal microbiota alters the gut-brain metabolome and prevents emotional dysfunction in the adult offspring of obese dams.
Journal article
Radford-Smith DE. et al, (2022), Proc Natl Acad Sci U S A, 119