Research groups
Colleges
Daniel C Anthony
Professor of Experimental Neuropathology
- Fellow of Somerville College
- Honorary Professor, University of Southern Denmark
- Fellow of the British Pharmacological Society
Daniel Anthony, a specialist in inflammatory disease, leads the Experimental Neuropathology Laboratory at the University of Oxford. As a Fellow of Somerville College and an Honorary Professor at the University of Southern Denmark, he has developed a niche in understanding how systemic inflammation influences the outcomes of both acute and chronic brain injuries and infections. His research interests also focus on the role of circulating extracellular vesicles in the pathogenesis of CNS diseases and the contribution of cytokine production to neuropsychiatric disorders.
Professor Anthony's career began with a Ph.D. from University College London in 1994, after which he joined Professor Hugh Perry in Oxford on a British Biotech Fellowship to explore metalloproteinase expression in the CNS. His work has led to the identification of novel biomarkers for diagnosing disease and predicting progression, leveraging a combination of in vivo biology, molecular biology, immunohistochemistry, MRI and PET imaging, and metabolomics. After a stint at the University of Southampton, where he was a Lecturer in Neurobiology, he returned to Oxford in 2004, where he continues to explore the neurobiology of inflammation with research collaborations throughout the world. In 2015, he was awarded a personal Chair in Experimental Neuropathology, and he was made a Fellow of the British Pharmacological Society in 2020.
Recent publications
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Metformin reprograms tryptophan metabolism via gut Microbiome-Derived bile acid metabolites to ameliorate Depression-Like behaviors in mice.
Journal article
Xie X. et al, (2024), Brain Behav Immun
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Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression
Journal article
Strekalova T. et al, (2024), Neurobiology of Stress, 31
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Ex-Vivo 13C NMR Spectroscopy of Rodent Brain: TNF Restricts Neuronal Utilization of Astrocyte-Derived Metabolites.
Journal article
Radford-Smith D. et al, (2024), J Proteome Res
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Sodium fluoride preserves blood metabolite integrity for biomarker discovery in large-scale, multi-site metabolomics investigations.
Journal article
Xiong W. et al, (2024), Analyst
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Distinct plasma metabolomic signatures differentiate autoimmune encephalitis from drug-resistant epilepsy
Journal article
Xiong W. et al, (2024), Annals of Clinical and Translational Neurology