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Research groups

Latest Features

'Mouse Brains Appear to Eavesdrop on Their Fat' (The Scientist, September 2022)

The paper, 'Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects' has been featured in:

The paper, 'Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine' has been featured in:

The paper, 'Sympathetic neuro-adipose connections mediate leptin-driven lipolysis' has been featured in:

The first PhD student of the Domingos lab to graduate, Roksana Pirzgalska, has been featured in:

The second PhD student of the Domingos lab to graduate, Ines Mahu, has been featured in Cell Metabolism:

Ana Domingos

Professor of Neuroscience

  • Tutor of Medicine at Lady Margaret Hall
  • OUI Innovation Champion

The Domingos laboratory researches neuroimmune mechanisms underlying obesity. They discovered neuro-adipose junctions, between white adipocytes and sympathetic neurons, that are necessary and sufficient for fat mass reduction via norepinephrine (NE) signalling. Moreover, they discovered Sympathetic neuron-Associated Macrophages (SAMs) that import and metabolize NE. Abrogation of SAM function promotes long-term amelioration of obesity independently of food intake. These findings inspired the development of a new class of anti-obesity compounds named sympathofacilitators, which do not enter the brain, nor have the typical cardiovascular side effects of centrally acting sympathomimetic drugs.  Sympathofacilitator drugs act as an energy sink by coupling thermogenesis to active heat dissipation. Ana Domingos is a member of the advisory board of Cell Metabolism and her lab has been funded by HHMI, Wellcome Trust, ERC, HFSP, EMBO, among others.

Ana speaks at IMMUNOGLOBAL  talks

© Global Immunotalks

Neuroimmunometabolism, by Prof Ana Domingos

© Oxford University Scientific Society

Optogenetics in NeuroImmunity

Speaking at

Organisation of conferences

Past Meetings

BDI - MDO 2022, "Metabolic Diseases; Breakthrough Discoveries in Diabetes & Obesity", October 23-26 2022.

Neuroimmunometabolism, Icahn School of Medicine at Mount Sinai, Brain and Body Seminar series, October 5 2022.

Sidra Medicine's Precision Medicine and Functional Genomics 2022, "Neuroimmunometabolism", September 25 2022.

Complement UK, "Novel Mechanisms, Tools, and Therapies in Neuroinflammation", September 8-9 2022, King's College London. 

Cell Symposia, "Translational Immunometabolism", June 26-28 2022, Basel, Switzerland.

EMBO|FEBS Lecture Course, "Molecular mechanisms of interorgan crosstalk in health and disease", May 19-27 2022, Spetses, Greece.

Cell Symposia, "Metabolites in Signaling and Disease", April 3-5 2022, Lisbon, Portugal.

EMNO | EMBL Symposium, Inter-organ communication in physiology and disease, March 21-23 2022, online.

GRK1957, 3rd  Adipocyte-Brain Crosstalk Symposium, March 10-11 2022, online. Keynote Lecture.

Broad Institute of MIT and Harvard's 31st Center for the Study of Inflammatory Bowel Disease (CSIBD) Workshop and 2nd Broad Immunology Symposium, November 18 and November 19 2021

Nature Conference, “Metabolism in Health and Disease”, organised by Nature Cell Biology, Nature Metabolism and Nature Reviews Molecular Cell Biology, June 28-30, 2021.

Abcam Conference, "Immunometabolism: Fundamentals to Prospective New Therapies," June 8, 2021. Talk title "Sympathetic Neuroimmunometabolism"  View full programme.

Keystone eSymposia, Single Cell Biology, Wednesday 17 March 2021. Download the eSymposia program or view online here.

Keystone Symposia, Obesity: From Cell to Patient, February 1 -3 2021. See programme here.

Keystone Symposia, Integrating Metabolism and Immunity, January 25 - 28 2021. See programme here.

MRC London Institute of Medical Sciences, Inter-organ Communication in Health and Disease Virtual Symposium, November 24 2020

Naomi Berrie Diabetes Center Seminars at Columbia University, “Sympathetic Neuroimmunity in Obesity”, November 12 2020

Cell Symposia, Metabolites in Signalling and Disease, Lisbon, Portugal, October 25 - 27 2020

American Diabetes Association, 80th Scientific Sessions (#ADA2020), Virtual Meeting "Immunity, Metabolism, and Diabetes", June 13 2020 5pm

Neuroscience School of Advanced Studies (NSAS), Neuroscience of Obesity, Venice, Italy, June 6 - 13 2020

Gastronauts Zoom-side Chat: Why we self medicate, Virtual Meeting, Tuesday 7 April 2020

Nature Conferences, Advances in Metabolic Communication, Rio de Janeiro, Brazil, October 15 - 18 2019

Cell Symposia, Neuro-Immune Axis: Reciprocal Regulation in Development, Health and Disease, Long Beach, California, September 22-24 2019

ICMS, 14th World Congress on Inflammation (WCI2019), Sydney, September 15-19 2019. Plenary speakers included Janelle Ayres (The Salk Institute), Daniel Cua (Merck), Vishva M. Dixit (Genentech, Inc.), Florent Ginhoux (Singapore Immunology Network), Elaine Holmes (Imperial College London), Paul Kubes (University of Calgary), Luke O'Neill (Trinity College Dubin), Michal Schwartz (Weizmann Institute of Science) and Carola Vinuesa (Australian National University)

Aegean Conferences, 4th International Conference on ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism, Rhodes, Greece May 28  - June 2 2019

EMBO Workshop, Organ crosstalk in energy balance and metabolic disease, Sancti Petri, Chiclana, Cádiz, Spain,  April 8-11 2019

Type 2 Immunity in Homeostasis and Disease - 21-22 February 2019

Key publications

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