Ana Domingos reflects on past experiences working with DPAG's inaugural Hans Krebs Lecture speaker, Jeffrey Friedman, who has been awarded the Breakthrough Prize in Life Sciences. Read more here.
A collaborative research team from the Universities of Oxford and Cambridge co-led by Ana Domingos have developed a new weight-loss amphetamine that could potentially avoid the harmful side effects of traditional treatments. Read more here.
Associate Professor of Neuroscience
- Tutor of Medicine at Lady Margaret Hall
- OUI Innovation Champion
The Domingos laboratory researches neuroimmune mechanisms underlying obesity. They discovered the sympathetic neuro-adipose junction, a functional synapse-like connection between white adipocytes and the sympathetic nervous system (Cell 2015). They found that this neuro-adipose junction is necessary and sufficient for fat mass reduction via norepinephrine (NE) signaling (Cell 2015, Nature Comm 2017). They then discovered Sympathetic neuron-Associated Macrophages (SAMs) that directly import and metabolize NE. Abrogation of SAM function promotes long-term amelioration of obesity independently of food intake (Nature Medicine, 2017).
Cell Symposia, Metabolites in Signalling and Disease, Lisbon, Portugal, October 25 - 27 2020
MRC London Institute of Medical Sciences, Inter-organ Communication in Health and Disease Virtual Symposium, November 24 2020, Session 1: ‘Signalling stress and disease’ 2:20 – 2:30 pm. Register here.
GRC, Neuroimmunology in Organismic Function: Shared Mechanisms and Reciprocal Interactions, California, USA, January 24 - 29 2021.
Keystone Symposia, Obesity: From Cell to Patient, Vancouver, Canada, January 29 - February 2 2021.
GRC, Gordon Research Conference: Immune System in Health, Disease and Therapy, Castelldefels, Spain, Postponed to 2022.
The paper, 'Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects' has been featured in:
Brain-sparing sympathofacilitators mitigate obesity without adverse cardiovascular effects
DOMINGOS ANA. and mahu I., (2020), Cell Metabolism
Sarker G. et al, (2020), Nat Immunol
Larabee CM. et al, (2019), Nature Reviews Endocrinology
Domingos AI., (2019), Nature Reviews Immunology
Berger JM. et al, (2019), Cell Metab, 30, 890 - 902.e8
Pirzgalska RM. et al, (2017), Nat Med, 23, 1309 - 1318
Chaudhury D. et al, (2013), Nature, 493, 532 - 536