Ana Domingos reflects on past experiences working with DPAG's inaugural Hans Krebs Lecture speaker, Jeffrey Friedman, who has been awarded the Breakthrough Prize in Life Sciences. Read more here.
Associate Professor of Neuroscience
- Tutor of Medicine at Lady Margaret Hall
The Domingos laboratory researches neuroimmune mechanisms underlying obesity. They discovered the sympathetic neuro-adipose junction, a functional synapse-like connection between white adipocytes and the sympathetic nervous system (Cell 2015). They found that this neuro-adipose junction is necessary and sufficient for fat mass reduction via norepinephrine (NE) signaling (Cell 2015, Nature Comm 2017). They then discovered Sympathetic neuron-Associated Macrophages (SAMs) that directly import and metabolize NE. Abrogation of SAM function promotes long-term amelioration of obesity independently of food intake (Nature Medicine, 2017).
Keystone Symposia, Integrating Metabolism and Immunity, Colorado, USA, April 3 - 7 2020
Neuroscience School of Advanced Studies (NSAS), Neuroscience of Obesity, Venice, Italy, June 6 - 13 2020
GRC, Gordon Research Conference: Immune System in Health, Disease and Therapy, Castelldefels, Spain, June 7 - 12 2020
American Diabetes Association, 80th Scientific Sessions (#ADA2020), Chicago, Illinois, USA, June 12 - 16 2020
Berger JM. et al, (2019), Cell Metab, 30, 890 - 902.e8
Larabee CM. et al, (2019), Nature Reviews Endocrinology
Domingos AI., (2019), Nature Reviews Immunology
Sarker G. et al, (2020), Nat Immunol