Alex Clark

Post doctoral research fellow

My research interests are in the fields of inherited causes of pain and the myelination of peripheral neurons.

I am using a recently developed approach to differentiate induced pluripotent stem cells (ipsc) into sensory neurons. This technique is then used to investigate genetically acquired pain disorders in culture based assays. I am also working on establishing myelinating cocultures using human ipsc-derived neurons with the aim to use these to understand the pathophysiology of demyelinating neuropathies.

Recent publications

Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth.
Journal article

Baskozos G. et al, (2020), Brain, 143, 2009 - 2026
Establishing Myelinating Cocultures Using Human iPSC-Derived Sensory Neurons to Investigate Axonal Degeneration and Demyelination.
Journal article

Clark AJ., (2020), Methods Mol Biol, 2143, 111 - 129
The Role of Voltage-Gated Sodium Channels in Pain Signaling.
Journal article

Bennett DL. et al, (2019), Physiol Rev, 99, 1079 - 1151
Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury.
Journal article

Baskozos G. et al, (2019), Pain, 160, 463 - 485
Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro.
Journal article

Wilson ER. et al, (2018), Neurobiol Dis, 117, 1 - 14

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