- BBSRC David Phillips Fellow
- Lecturer, Oriel College
Aarti Jagannath is a BBSRC David Phillips Fellow at the Sleep and Circadian Neuroscience Institute within the Nuffield Department of Clinical Neuroscience. Her group researches the molecular mechanisms that regulate circadian clock entrainment.
All organisms show 24h rhythms in their physiology and behaviour, orchestrated by a circadian clock that coordinates internal time with the external world. Aarti’s research aims to understand the molecular mechanisms by which the circadian clock picks up cues from the external environment and is set to the right time. Circadian rhythm disruption is endemic in today’s 24/7 lifestyle, and can precipitate a range of chronic conditions such as cancer and metabolic syndrome and a better understanding of how the clock is regulated can lead to novel interventions.
Aarti read for a DPhil on the mechanisms of RNA interference at Brasenose college Oxford and subsequently joined the SCNi as a Roche Post-Doctoral Fellow in to work on the circadian clock. She was awarded the L’Oreal Women in Science Fellowship in 2015 and is also Lecturer at Oriel College.
The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.
Jagannath A. et al, (2013), Cell, 154, 1100 - 1111
Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.
Jagannath A. et al, (2021), Nat Commun, 12
Circadian regulation of SARS-CoV-2 infection in lung epithelial cells.
Zhuang X. et al, (2021), bioRxiv
Cold-induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm.
Fischl H. et al, (2020), EMBO J, 39
Cold-induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm
FISCHL H. et al, (2020), The EMBO Journal
Cold induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm
FISCHL H. et al, (2020), biorxiv