- BBSRC David Phillips Fellow
- Lecturer, Oriel College
Aarti Jagannath is a BBSRC David Phillips Fellow at the Sleep and Circadian Neuroscience Institute within the Nuffield Department of Clinical Neuroscience. Her group researches the molecular mechanisms that regulate circadian clock entrainment.
All organisms show 24h rhythms in their physiology and behaviour, orchestrated by a circadian clock that coordinates internal time with the external world. Aarti’s research aims to understand the molecular mechanisms by which the circadian clock picks up cues from the external environment and is set to the right time. Circadian rhythm disruption is endemic in today’s 24/7 lifestyle, and can precipitate a range of chronic conditions such as cancer and metabolic syndrome and a better understanding of how the clock is regulated can lead to novel interventions.
Aarti read for a DPhil on the mechanisms of RNA interference at Brasenose college Oxford and subsequently joined the SCNi as a Roche Post-Doctoral Fellow in to work on the circadian clock. She was awarded the L’Oreal Women in Science Fellowship in 2015 and is also Lecturer at Oriel College.
The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.
Jagannath A. et al, (2013), Cell, 154, 1100 - 1111
Differential roles for cryptochromes in the mammalian retinal clock.
Wong JCY. et al, (2018), FASEB J
The genetics of circadian rhythms, sleep and health.
Jagannath A. et al, (2017), Hum Mol Genet, 26, R128 - R138
Constant Light Desynchronizes Olfactory versus Object and Visuospatial Recognition Memory Performance.
Tam SKE. et al, (2017), J Neurosci, 37, 3555 - 3567
Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light.
Pilorz V. et al, (2016), PLoS Biol, 14
Signalling by melanopsin (OPN4) expressing photosensitive retinal ganglion cells.
Hughes S. et al, (2016), Eye (Lond), 30, 247 - 254