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Publications

Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons.

Bogetofte H. et al, (2023), Cell Rep, 42

Identification of a possible proteomic Biomarker in Parkinson’s Disease: Discovery and Replication in Blood, brain and CSF

WINCHESTER L. and NEVADO-HOLGADO A., (2022), Brain Communications

Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.

Carling PJ. et al, (2022), Autophagy, 1 - 14

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.

Fdez E. et al, (2022), iScience, 25

Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.

Burley S. et al, (2022), Sci Rep, 12

Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.

Ng B. et al, (2022), Brain Commun, 4

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.

Ng J. et al, (2021), Sci Transl Med, 13

REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model.

Ryan BJ. et al, (2021), J Neurosci

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease.

Bengoa-Vergniory N. et al, (2021), Acta Neuropathol Commun, 9

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.

Vilema-Enríquez G. et al, (2020), J Biol Chem, 295, 17973 - 17985

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.

Roberts BM. et al, (2020), Nat Commun, 11

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.

Bengoa-Vergniory N. et al, (2020), Nat Commun, 11

Cohort Profile: the Oxford Parkinson's Disease Centre Discovery Cohort Magnetic Resonance Imaging sub-study (OPDC-MRI)

GRIFFANTI L. et al, (2020), BMJ Open

Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons.

Monzón-Sandoval J. et al, (2020), Ann Neurol, 87, 853 - 868

The Dementias Platform UK (DPUK) Data Portal.

Bauermeister S. et al, (2020), Eur J Epidemiol, 35, 601 - 611

LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.

Lee H. et al, (2020), Stem Cell Reports, 14, 940 - 955

Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.

Carling PJ. et al, (2020), Prog Neurobiol, 187

Understanding the pathophysiological role of early tau aggregates in Alzheimer's disease by their direct visualisation in situ

Velentza-Almpani E. et al, (2020), NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 46, 42 - 42

Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits.

Simanaviciute U. et al, (2020), J Neurosci Methods, 331

"LRRK2: Autophagy and Lysosomal Activity".

Madureira M. et al, (2020), Front Neurosci, 14

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