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Publications

Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.

Burley S. et al, (2022), Sci Rep, 12

REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model.

Ryan BJ. et al, (2021), J Neurosci

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease.

Bengoa-Vergniory N. et al, (2021), Acta Neuropathol Commun, 9

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.

Vilema-Enríquez G. et al, (2020), J Biol Chem, 295, 17973 - 17985

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.

Bengoa-Vergniory N. et al, (2020), Nat Commun, 11

Cohort Profile: the Oxford Parkinson's Disease Centre Discovery Cohort Magnetic Resonance Imaging sub-study (OPDC-MRI)

GRIFFANTI L. et al, (2020), BMJ Open

Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons.

Monzón-Sandoval J. et al, (2020), Ann Neurol, 87, 853 - 868

The Dementias Platform UK (DPUK) Data Portal.

Bauermeister S. et al, (2020), Eur J Epidemiol, 35, 601 - 611

LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.

Lee H. et al, (2020), Stem Cell Reports, 14, 940 - 955

Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.

Carling PJ. et al, (2020), Prog Neurobiol, 187

Understanding the pathophysiological role of early tau aggregates in Alzheimer's disease by their direct visualisation in situ

Velentza-Almpani E. et al, (2020), NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 46, 42 - 42

Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits.

Simanaviciute U. et al, (2020), J Neurosci Methods, 331

"LRRK2: Autophagy and Lysosomal Activity".

Madureira M. et al, (2020), Front Neurosci, 14

What we can learn from iPSC-derived cellular models of Parkinson's disease.

Caiazza MC. et al, (2020), 252, 3 - 25

Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons.

Überbacher C. et al, (2019), Stem Cell Res, 41

Perturbations in RhoA signalling cause altered migration and impaired neuritogenesis in human iPSC-derived neural cells with PARK2 mutation.

Bogetofte H. et al, (2019), Neurobiol Dis, 132

Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease.

Benkert J. et al, (2019), Nat Commun, 10

Lysosomal Dysfunction at the Centre of Parkinson's Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis.

Wallings RL. et al, (2019), Trends Neurosci

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.

Hunn BHM. et al, (2019), Cell Rep, 29, 920 - 931.e7

The neuronal calcium sensor NCS-1 is involved in defining vulnerability of Substantia nigra dopaminergic neurons to degenration in Parkinson's disease

Simons C. et al, (2019), ACTA PHYSIOLOGICA, 227

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