Early deficits in an in vitro striatal microcircuit model carrying the Parkinson's GBA-N370S mutation.
Journal article
Do QB. et al, (2024), NPJ Parkinsons Dis, 10
Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease.
Journal article
Kilfeather P. et al, (2024), Cell Rep, 43
Tau depletion in human neurons mitigates Aβ-driven toxicity.
Journal article
Ng B. et al, (2024), Mol Psychiatry
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Journal article
WADE-MARTINS R., (2023), Molecular Neurodegeneration, 18
Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's.
Journal article
Brimblecombe KR. et al, (2023), Eur J Neurosci
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.
Journal article
Vahsen BF. et al, (2023), Nat Commun, 14
Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models.
Journal article
Williamson MG. et al, (2023), Hum Mol Genet
Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons.
Journal article
Bogetofte H. et al, (2023), Cell Rep, 42
Identification of a possible proteomic biomarker in Parkinson's disease: discovery and replication in blood, brain and cerebrospinal fluid.
Journal article
Winchester L. et al, (2023), Brain Commun, 5
Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.
Journal article
Carling PJ. et al, (2022), Autophagy, 1 - 14
Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.
Journal article
Fdez E. et al, (2022), iScience, 25
Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.
Journal article
Burley S. et al, (2022), Sci Rep, 12
Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.
Journal article
Ng B. et al, (2022), Brain Commun, 4
Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.
Journal article
Ng J. et al, (2021), Sci Transl Med, 13
REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model.
Journal article
Ryan BJ. et al, (2021), J Neurosci
Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease.
Journal article
Bengoa-Vergniory N. et al, (2021), Acta Neuropathol Commun, 9
Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
Journal article
Vilema-Enríquez G. et al, (2020), J Biol Chem, 295, 17973 - 17985
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Journal article
Roberts BM. et al, (2020), Nat Commun, 11
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.
Journal article
Bengoa-Vergniory N. et al, (2020), Nat Commun, 11
Cohort Profile: the Oxford Parkinson's Disease Centre Discovery Cohort Magnetic Resonance Imaging sub-study (OPDC-MRI)
Journal article
GRIFFANTI L. et al, (2020), BMJ Open