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Publications

RNase H2, mutated in Aicardi-Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation.

Cristini A. et al, (2022), Nat Commun, 13

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes.

Giordano AMS. et al, (2022), J Exp Med, 219

R-Loop Immunoprecipitation: A Method to Detect R-Loop Interacting Factors.

Beghè C. and Gromak N., (2022), Methods Mol Biol, 2528, 215 - 237

Hypoxia-induced SETX links replication stress with the unfolded protein response.

Ramachandran S. et al, (2021), Nat Commun, 12

Hypoxia-induced SETX links replication stress with the unfolded protein response.

Hammond EM., (2021), 27

Transcription-dependent DNA double-strand breaks and human disease.

Cristini A. et al, (2020), Mol Cell Oncol, 7

N6-methyladenosine regulates the stability of RNA:DNA hybrids in 1human cells

GROMAK N., (2019), Nature Genetics

Dual processing of R-loops and topoisomerase I induces transcription-dependent DNA double-strand breaks

CRISTINI A. et al, (2019), Cell Reports

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage.

Cristini A. et al, (2018), Cell Rep, 23, 1891 - 1905

Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin

Brustel J. et al, (2018), Scientific Reports

Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin.

Brustel J. et al, (2018), Sci Rep, 8

Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration.

Groh M. et al, (2017), J Mol Biol, 429, 3181 - 3195

Increased global transcription activity as a mechanism of replication stress in cancer.

Kotsantis P. et al, (2016), Nat Commun, 7

Out of balance: R-loops in human disease.

Groh M. and Gromak N., (2014), PLoS Genet, 10

Mechanisms of transcriptional dysregulation in repeat expansion disorders.

Groh M. et al, (2014), Biochem Soc Trans, 42, 1123 - 1128

Drosha Regulates Gene Expression Independently of RNA Cleavage Function.

Gromak N. et al, (2014), Cell Rep, 7, 1753 - 1754

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.

Groh M. et al, (2014), PLoS Genet, 10

Drosha regulates gene expression independently of RNA cleavage function.

Gromak N. et al, (2013), Cell Rep, 5, 1499 - 1510

Intronic microRNAs: a crossroad in gene regulation.

Gromak N., (2012), Biochem Soc Trans, 40, 759 - 761

Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.

Skourti-Stathaki K. et al, (2011), Mol Cell, 42, 794 - 805

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