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Publications

Transcription-dependent DNA double-strand breaks and human disease.

Cristini A. et al, (2020), Mol Cell Oncol, 7

N6-methyladenosine regulates the stability of RNA:DNA hybrids in 1human cells

GROMAK N., (2019), Nature Genetics

Dual processing of R-loops and topoisomerase I induces transcription-dependent DNA double-strand breaks

CRISTINI A. et al, (2019), Cell Reports

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage.

Cristini A. et al, (2018), Cell Rep, 23, 1891 - 1905

Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin

Brustel J. et al, (2018), Scientific Reports

Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration.

Groh M. et al, (2017), J Mol Biol, 429, 3181 - 3195

Increased global transcription activity as a mechanism of replication stress in cancer.

Kotsantis P. et al, (2016), Nat Commun, 7

Out of balance: R-loops in human disease.

Groh M. and Gromak N., (2014), PLoS Genet, 10

Mechanisms of transcriptional dysregulation in repeat expansion disorders.

Groh M. et al, (2014), Biochem Soc Trans, 42, 1123 - 1128

Drosha Regulates Gene Expression Independently of RNA Cleavage Function.

Gromak N. et al, (2014), Cell Rep, 7, 1753 - 1754

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.

Groh M. et al, (2014), PLoS Genet, 10

Drosha regulates gene expression independently of RNA cleavage function.

Gromak N. et al, (2013), Cell Rep, 5, 1499 - 1510

Intronic microRNAs: a crossroad in gene regulation.

Gromak N., (2012), Biochem Soc Trans, 40, 759 - 761

Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.

Skourti-Stathaki K. et al, (2011), Mol Cell, 42, 794 - 805

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.

Webby CJ. et al, (2009), Science, 325, 90 - 93

Primary microRNA transcripts are processed co-transcriptionally.

Morlando M. et al, (2008), Nat Struct Mol Biol, 15, 902 - 909

Primary microRNA transcripts are processed co-transcriptionally.

Morlando M. et al, (2008), Nat Struct Mol Biol

Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA.

Gromak N. et al, (2008), RNA, 14, 359 - 366

Pause sites promote transcriptional termination of mammalian RNA polymerase II.

Gromak N. et al, (2006), Mol Cell Biol, 26, 3986 - 3996

Exon tethering in transcription by RNA polymerase II.

Dye MJ. et al, (2006), Mol Cell, 21, 849 - 859

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