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Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops.
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SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops
GROMAK N., (2023), Molecular Cell
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
GROMAK N., (2023), Nature Genetics
What repeat expansion disorders can teach us about the Central Dogma.
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APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
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RNase H2, mutated in Aicardi-Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation.
Cristini A. et al, (2022), Nat Commun, 13
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes.
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R-Loop Immunoprecipitation: A Method to Detect R-Loop Interacting Factors.
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Hypoxia-induced SETX links replication stress with the unfolded protein response.
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Transcription-dependent DNA double-strand breaks and human disease.
Cristini A. et al, (2020), Mol Cell Oncol, 7
N6-methyladenosine regulates the stability of RNA:DNA hybrids in 1human cells
GROMAK N., (2019), Nature Genetics
Dual processing of R-loops and topoisomerase I induces transcription-dependent DNA double-strand breaks
CRISTINI A. et al, (2019), Cell Reports
RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage.
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Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin
Brustel J. et al, (2018), Scientific Reports
Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin.
Brustel J. et al, (2018), Sci Rep, 8
Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration.
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Increased global transcription activity as a mechanism of replication stress in cancer.
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