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A facile method for the regioselective hydrodifluoromethylation of alkenes is reported using difluoroacetic acid and phenyliodine(III) diacetate in tetrahydrofuran under visible-light activation. This metal-free approach stands out as it uses inexpensive reagents, does not require a photocatalyst, and displays broad functional group tolerance. The procedure is also operationally simple and scalable, and provides access in one step to high-value building blocks for application in medicinal chemistry.

Original publication

DOI

10.1002/anie.201903801

Type

Journal article

Journal

Angew Chem Int Ed Engl

Publication Date

24/06/2019

Volume

58

Pages

8829 - 8833

Keywords

difluoroacetic acid, hydrodifluoromethylation, hypervalent iodine compounds, photochemistry, radicals