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A putative origin of DNA replication is associated with the DNA sequences necessary for the repression of silent mating type loci in yeast. These sequences lie about a kilobase away from the affected promoters, so the repression must act at a distance. We show here that DNA replication is required for the onset of repression.

Type

Journal article

Journal

Nature

Publication Date

15/11/1984

Volume

312

Pages

247 - 251

Keywords

Animals, DNA Replication, Fungal Proteins, Gene Expression Regulation, Mating Factor, Peptides, Pheromones, Recombination, Genetic, Saccharomyces cerevisiae