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Loss of cohesion between sister chromatids triggers their segregation during anaphase. Recent work has identified both a cohesin complex that holds sisters together and a sister-separating protein, separin, that destroys cohesion. Separins are bound by inhibitory proteins whose proteolysis at the metaphase-anaphase transition is mediated by the anaphase-promoting complex and its activator protein CDC20 (APCCDC20). When chromosomes are misaligned, a surveillance mechanism (checkpoint) blocks sister separation by inhibiting APCCDC20. Defects in this apparatus are implicated in causing aneuploidy in human cells.


Journal article


Trends Biochem Sci

Publication Date





98 - 104


Anaphase, Anaphase-Promoting Complex-Cyclosome, Animals, Cell Cycle Proteins, Chromatids, Humans, Ligases, Meiosis, Metaphase, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases