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A multisubunit complex, called cohesin, containing Smc1p, Smc3p, Scc1p, and Scc3p, is required for sister chromatid cohesion in mitotic cells. We show here that Smc3p and a meiotic version of Scc1p called Rec8p are required for cohesion between sister chromatids, for formation of axial elements, for reciprocal recombination, and for preventing hyperresection of double-strand breaks during meiosis. Both Rec8p and Smc3p colocalize with chromosome cores independently of synapsis during prophase I and largely disappear from chromosome arms after pachytene but persist in the neighborhood of centromeres until the onset of anaphase II. The eukaryotic cell's cohesion apparatus is required both for the repair of recombinogenic lesions and for chromosome segregation and therefore appears to lie at the heart of the meiotic process.

Original publication

DOI

10.1016/S0092-8674(00)80609-1

Type

Journal article

Journal

Cell

Publication Date

09/07/1999

Volume

98

Pages

91 - 103

Keywords

Anaphase, Animals, Cell Cycle, Cell Cycle Proteins, Centromere, Chondroitin Sulfate Proteoglycans, Chromatids, Chromosomal Proteins, Non-Histone, Fungal Proteins, Humans, Meiosis, Nuclear Proteins, Phosphoproteins, Phylogeny, Recombination, Genetic, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins