Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Certain cell types give rise to progeny that adopt different patterns of gene expression in the absence of any differences in their environment. Cells of budding yeast give birth to mother and daughter cells that differ in that only mother cells express the HO endonuclease gene and thereby switch mating types. We describe the identification of five genes, called SHE1-SHE5, that encode cytoplasmic proteins required for mother-specific HO expression. She1p, which is identical to the minimyosin Myo4p, and She3p are not, however, mother-specific proteins. On the contrary, they accumulate in growing buds. She proteins might be required for the transport of factors that promote HO repression from the mother cell into its bud. In an accompanying paper, we show that SHE genes are needed for the accumulation in daughter nuclei of Ash1p, a repressor of HO.


Journal article



Publication Date





687 - 697


Cell Cycle, Cloning, Molecular, Crosses, Genetic, Cytoplasm, Cytoskeletal Proteins, Deoxyribonucleases, Type II Site-Specific, Enzyme Repression, Fungal Proteins, Gene Expression, Gene Expression Regulation, Fungal, Genes, Fungal, Genomic Library, Mutagenesis, Myosin Heavy Chains, Myosin Type V, Myosins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transformation, Genetic