Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Sexually reproducing organisms rely on the precise reduction of chromosome number during a specialized cell division called meiosis. Whereas mitosis produces diploid daughter cells from diploid cells, meiosis generates haploid gametes from diploid precursors. The molecular mechanisms controlling chromosome transmission during both divisions have started to be delineated. This review focuses on the four fundamental differences between mitotic and meiotic chromosome segregation that allow the ordered reduction of chromosome number in meiosis: (1) reciprocal recombination and formation of chiasmata between homologous chromosomes, (2) suppression of sister kinetochore biorientation, (3) protection of centromeric cohesion, and (4) inhibition of DNA replication between the two meiotic divisions.

Type

Journal article

Journal

Cell

Publication Date

21/02/2003

Volume

112

Pages

423 - 440

Keywords

Anaphase, Animals, Aurora Kinases, Chromatin, Chromosome Segregation, Kinetochores, Meiosis, Mitosis, Models, Biological, Protein-Serine-Threonine Kinases, Recombination, Genetic, Saccharomyces cerevisiae