Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Brain weight is often said to be decreased in schizophrenia, but a reduction has only been found in a minority of studies. We have therefore carried out a meta-analysis to answer this basic neuropathological question. Data were identified from literature searches and from contacting researchers in the field who were invited to submit unpublished data. Inclusion criteria were: an operational diagnosis of schizophrenia, or comparison subjects with no neurological or psychiatric history, aged 18 or over, for whom brain weight, age and sex were known. Exclusion criteria were: a history of head injury, epilepsy, substance dependence or leucotomy; neuropathological evidence of neurodegenerative disorder or focal brain lesion. Results were analysed by multilevel modelling. Brain weight was, as expected, related to age and sex (both p<0.0001). After control for these factors, there was an effect of diagnosis, with brains from the 540 schizophrenia subjects being 2% lighter than from the 794 controls (weighted mean difference=24 g [95% confidence interval, 1-47 g]; p=0.04). The difference was similar in male and female patients. There was no correlation with duration of illness. In conclusion, brain weight is slightly but significantly reduced in schizophrenia, consistent in direction and magnitude with MRI volumetric findings. The result encourages a continuing search for the histological and molecular correlates of schizophrenia.

Type

Journal article

Journal

Schizophr Res

Publication Date

01/11/2003

Volume

64

Pages

25 - 34

Keywords

Adolescent, Adult, Aged, Aged, 80 and over, Brain, Data Interpretation, Statistical, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales, Reference Values, Schizophrenia, Schizophrenic Psychology