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B and T lymphocytes develop normally in mice lacking the guanine nucleotide exchange factor Vav-2. However, the immune responses to type II thymus-independent antigen as well as the primary response to thymus-dependent (TD) antigen are defective. Vav-2-deficient mice are also defective in their ability to switch immunoglobulin class, form germinal centers and generate secondary immune responses to TD antigens. Mice lacking both Vav-1 and Vav-2 contain reduced numbers of B lymphocytes and display a maturational block in the development of mature B cells. B cells from Vav-1(-/-)Vav-2(-/-) mice respond poorly to antigen receptor triggering, both in terms of proliferation and calcium release. These studies show the importance of Vav-2 in humoral immune responses and B cell maturation.

Original publication

DOI

10.1038/88748

Type

Journal article

Journal

Nat Immunol

Publication Date

06/2001

Volume

2

Pages

542 - 547

Keywords

Animals, Antibody Formation, Antigens, Differentiation, T-Lymphocyte, Antigens, T-Independent, B-Lymphocytes, Cell Cycle Proteins, Cell Differentiation, Mice, Mice, Knockout, Oncogene Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-vav, Signal Transduction