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B-cell development and function requires the products of the Vav family of genes. Vav proteins act as key components of the antigen receptor signal transduction machinery by integration of signals that control the cell cycle, differentiation and apoptosis. At the molecular level, Vav proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux.

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

08/2002

Volume

30

Pages

812 - 815

Keywords

Animals, B-Lymphocytes, Cell Cycle Proteins, Humans, Mice, Mice, Knockout, Oncogene Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-vav, Receptors, Antigen, B-Cell, Signal Transduction