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Sequence-specific RNA-binding proteins (RBP) and the regulation of RNA decay have long been recognized as important regulators of the inflammatory response. RBP influence gene expression throughout the lifespan of the mRNA by regulating splicing, polyadenylation, cellular localization, translation, and decay. Increasing evidence now indicates that these proteins, together with the RNA decay machinery that they recruit, also regulate the development and activation of lymphocytes. The activity of RBP is regulated by the same signal transduction pathways that govern lymphocyte development and differentiation in response to antigen and cytokine receptor engagement. Roles for these proteins in regulating the diverse functions of lymphocytes are becoming increasingly apparent.

Original publication

DOI

10.1016/B978-0-12-394299-9.00006-0

Type

Journal article

Journal

Adv Immunol

Publication Date

2012

Volume

115

Pages

161 - 185

Keywords

B-Lymphocytes, Cell Differentiation, Cytokines, Gene Expression Regulation, Humans, Lymphocyte Activation, Protein Biosynthesis, RNA Splicing, RNA Stability, RNA, Messenger, RNA-Binding Proteins, Receptors, Cytokine, Signal Transduction, T-Lymphocytes