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The rapid changes in gene expression that accompany developmental transitions, stress responses and proliferation are controlled by signal-mediated coordination of transcriptional and post-transcriptional mechanisms. In recent years, understanding of the mechanics of these processes and the contexts in which they are employed during hematopoiesis and immune challenge has increased. An important aspect of this progress is recognition of the importance of RNA-binding proteins and noncoding RNAs. These have roles in the development and function of the immune system and in pathogen life cycles, and they represent an important aspect of intracellular immunity.

Original publication




Journal article


Nat Immunol

Publication Date





484 - 491


Animals, Gene Expression, Hematopoiesis, Humans, Immune System, Immunity, Cellular, Lymphocyte Activation, Mice, RNA Processing, Post-Transcriptional, RNA, Long Noncoding, RNA, Small Untranslated, RNA-Binding Proteins, Signal Transduction, Transcription, Genetic