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The rapid changes in gene expression that accompany developmental transitions, stress responses and proliferation are controlled by signal-mediated coordination of transcriptional and post-transcriptional mechanisms. In recent years, understanding of the mechanics of these processes and the contexts in which they are employed during hematopoiesis and immune challenge has increased. An important aspect of this progress is recognition of the importance of RNA-binding proteins and noncoding RNAs. These have roles in the development and function of the immune system and in pathogen life cycles, and they represent an important aspect of intracellular immunity.

Original publication

DOI

10.1038/ni.2887

Type

Journal article

Journal

Nat Immunol

Publication Date

06/2014

Volume

15

Pages

484 - 491

Keywords

Animals, Gene Expression, Hematopoiesis, Humans, Immune System, Immunity, Cellular, Lymphocyte Activation, Mice, RNA Processing, Post-Transcriptional, RNA, Long Noncoding, RNA, Small Untranslated, RNA-Binding Proteins, Signal Transduction, Transcription, Genetic