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The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.

Original publication

DOI

10.1038/379131a0

Type

Journal article

Journal

Nature

Publication Date

11/01/1996

Volume

379

Pages

131 - 137

Keywords

Alleles, Animals, Base Sequence, Cell Line, Chimera, Clone Cells, DNA Primers, Dosage Compensation, Genetic, Embryo, Mammalian, Female, Gene Targeting, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Molecular Sequence Data, Mutagenesis, RNA, Long Noncoding, RNA, Untranslated, Restriction Mapping, Stem Cells, Transcription Factors, X Chromosome