Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

By performing immunoprecipitation assays of chromatin from the X inactivation center, it was determined that the upstream region of Xist is uniquely hyperacetylated in XX female ES cells, but not in male cells or in mutant cells in which the P1/P2 promoters of Xist have been deleted from one of the X chromosomes. Hyperacetylation declines during development, concomitant with X inactivation, but is not absolutely required for Xi to be inactivated. It is proposed that hyperacetylation of the 5' region of Xist facilitates the promoter switch that results in the stabilization of the Xist transcript, and ultimately X inactivation in cis. It is also suggested that the absence of 5' hyperacetylation of Xist in males protects the single X chromosome from promoter switching, and thus from inactivation.

Type

Journal article

Journal

Chemtracts

Publication Date

01/12/1999

Volume

12

Pages

960 - 968