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The past year has seen important progress in our understanding of the role of the X inactive specific transcript gene (Xist) in the initiation and propagation of X-inactivation. A 35 kb Xist transgene had been shown to recapitulate the functions of the X-inactivation centre, progress has been made towards indentifying factors controlling the randomness of X-inactivation, and RNA stabilisation has been shown to play a role in Xist regulation at the onset of X-inactivation.


Journal article


Curr Opin Genet Dev

Publication Date





328 - 333


Animals, Dosage Compensation, Genetic, Genes, Humans, RNA, Long Noncoding, RNA, Untranslated, Transcription Factors, X Chromosome