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A total of 17 linking clones previously sublocalized to the central span of the mouse X chromosome have been ordered by detailed analysis through interspecific Mus spretus/Mus musculus domesticus backcross progeny. These probes have been positioned with respect to existing DNA markers utilizing a new interspecific backcross segregating for the Tabby (Ta) locus. The density of clones within this 11.5-cM interval is now, on average, one clone every 1000 kb. This high-density map provides probes in the vicinity of a number of important genetic loci in this region which include the X-inactivation center, the Ta locus, and the mottled (Mo) locus, and therefore provides a molecular framework for identification of the genes encoded at these loci.

Type

Journal article

Journal

Genomics

Publication Date

05/1991

Volume

10

Pages

17 - 22

Keywords

Animals, Chromosome Mapping, Crosses, Genetic, DNA Probes, Genetic Linkage, Genetic Markers, Mice, Pedigree, Polymorphism, Restriction Fragment Length, X Chromosome