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The gene encoded at the human X-linked chronic granulomatous disease locus (cytochrome b245 beta subunit) has been mapped to the mouse X chromosome using an interspecific Mus domesticus x M. spretus cross. The localization of this gene provides detailed information on one of the proposed ancestral breakpoints that account for the divergent evolution of the mouse and human X chromosomes.

Original publication

DOI

10.1159/000132605

Type

Journal article

Journal

Cytogenet Cell Genet

Publication Date

1988

Volume

48

Pages

124 - 125

Keywords

Animals, Biological Evolution, Chromosome Mapping, Crosses, Genetic, Cytochrome b Group, DNA Probes, Female, Granulomatous Disease, Chronic, Humans, Male, Mice, Recombination, Genetic, Sequence Homology, Nucleic Acid, Sex Chromosome Aberrations, Species Specificity, X Chromosome