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We report the isolation and nucleotide sequence determination of clones derived from five ZFY-related zinc-finger genes from birds and mammals. These sequences are analyzed with reference to the previously published human genes, ZFX and ZFY, and mouse genes, Zfx, Zfa, Zfy-1, and Zfy-2. The analysis indicates that ZFY-related genes are highly conserved in birds and mammals, and that the rate of nucleotide substitution in the Y-linked genes is not as high as predicted. However, the mouse Zfy-1 and Zfy-2 genes are markedly divergent members of the ZFY gene family; we suggest this relates to X-inactivation of the mouse gene Zfx.


Journal article


J Mol Evol

Publication Date





310 - 315


Amino Acid Sequence, Animals, Base Sequence, Biological Evolution, Birds, Cloning, Molecular, Cricetinae, Cricetulus, Female, Foxes, Gene Amplification, Male, Molecular Sequence Data, Multigene Family, Species Specificity, Zinc Fingers