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Southern hybridization suggests that the zebrafish genome contains multiple zinc-finger genes related to the putative mouse developmental genes, Krox-20 and Krox-24. The polymerase chain reaction was employed to amplify and clone the zinc-finger regions of genes related to Krox-20, from two fish species and, for comparison, mouse, hamster and fox. DNA sequence analyses suggest that the genes cloned include the guppy homologue of Krox-20 and the zebrafish homologue of Krox-24, and that these genes diverged prior to the separation of the lineages leading to teleosts and to mammals.


Journal article


Biochem Biophys Res Commun

Publication Date





1220 - 1224


Amino Acid Sequence, Animals, Base Sequence, Blotting, Southern, Cell Line, DNA, Fishes, Genes, Liver, Mice, Mice, Inbred DBA, Molecular Sequence Data, Oligodeoxyribonucleotides, Poecilia, Polymerase Chain Reaction, Sequence Homology, Nucleic Acid, Zebrafish, Zinc Fingers