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Recent advances in techniques for visualising mRNA movement in living cells have led to rapid progress in understanding the mechanism of mRNA localisation in the cytoplasm. There is an emerging consensus that in many cases the mRNA signals that determine intracellular destination are more complex and difficult to define than was first anticipated. Furthermore, the transacting factors that interpret the mRNA signals are numerous and their combinations change during the life of an mRNA, perhaps allowing the selection of many sub-destinations in the cell. Lastly, an emerging theme over the past few years is that many proteins that determine the destinations of mRNAs are recruited on nascent transcripts in the nucleus. They often function in many different processes in the biogenesis of mRNA and probably act in concert to provide specificity.

Original publication

DOI

10.1016/j.ceb.2004.03.008

Type

Journal article

Journal

Curr Opin Cell Biol

Publication Date

06/2004

Volume

16

Pages

300 - 307

Keywords

Animals, Cell Nucleus, Cytoplasm, Humans, RNA Processing, Post-Transcriptional, RNA Splicing, RNA Stability, RNA, Messenger, RNA-Binding Proteins, Ribonucleoproteins, Trans-Activators