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Intracellular mRNA localization is a common mechanism of post-transcriptional regulation of gene expression. In a wide range of organisms, mRNA localization coupled with translational regulation target the proteins to their site of function. Here, we describe recent exciting evidence that some mRNAs are transported as particles along the cytoskeleton by the molecular motors dynein, kinesin or myosin. We discuss the key questions of how localized mRNAs might be linked to motors and what determines their cytoplasmic destinations.

Type

Journal article

Journal

Trends Genet

Publication Date

12/2002

Volume

18

Pages

636 - 642

Keywords

Animals, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Dyneins, Kinesin, Molecular Motor Proteins, Myosin Type V, RNA, Messenger, Trans-Activators, Transcription Factors, Yeasts