Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The N-methyl-D-aspartate (NMDA) receptor contributes to synaptic plasticity in the central nervous system and is both serine-threonine and tyrosine phosphorylated. In CA1 pyramidal neurons of the hippocampus, activators of protein kinase C (PKC) as well as the G-protein-coupled receptor ligands muscarine and lysophosphatidic acid enhanced NMDA-evoked currents. Unexpectedly, this effect was blocked by inhibitors of tyrosine kinases, including a Src required sequence and an antibody selective for Src itself. In neurons from mice lacking c-Src, PKC-dependent upregulation was absent. Thus, G-protein-coupled receptors can regulate NMDA receptor function indirectly through a PKC-dependent activation of the non-receptor tyrosine kinase (Src) signaling cascade.

Original publication

DOI

10.1038/7243

Type

Journal article

Journal

Nat Neurosci

Publication Date

04/1999

Volume

2

Pages

331 - 338

Keywords

Alkaloids, Amino Acid Sequence, Animals, Benzophenanthridines, Cells, Cultured, Enzyme Activation, Enzyme Inhibitors, GTP-Binding Proteins, Genistein, Isoflavones, Lysophospholipids, Mice, Mice, Knockout, Microinjections, Molecular Sequence Data, Muscarine, Nerve Tissue Proteins, Neuronal Plasticity, Oocytes, Patch-Clamp Techniques, Phenanthridines, Phenols, Phosphorylation, Protein Kinase C, Protein Processing, Post-Translational, Proto-Oncogene Proteins pp60(c-src), Pyramidal Cells, Rats, Rats, Wistar, Receptors, Cell Surface, Receptors, G-Protein-Coupled, Receptors, Lysophosphatidic Acid, Receptors, Muscarinic, Receptors, N-Methyl-D-Aspartate, Salicylates, Signal Transduction, Tetradecanoylphorbol Acetate, Xenopus laevis, meta-Aminobenzoates