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Caspases, key mediators of apoptosis, are a structurally related family of cysteine proteases that cleave their substrates at aspartic acid residues either to cause cell death or to activate cytokines as part of an immune response. They can be controlled upstream by the regulation of signals that lead to zymogen activation, or downstream by inhibitors that prevent them from reaching their substrates. This review specifically looks at caspase inhibitors as distinct from caspase regulators: those produced by the cell itself; those whose genes are carried by viruses; and artificial caspase inhibitors used for research and potentially as therapeutics.

Original publication

DOI

10.1038/sj.cdd.4402034

Type

Journal article

Publication Date

01/2007

Volume

14

Pages

73 - 78

Keywords

Animals, Caspase Inhibitors, Caspases, Cysteine Proteinase Inhibitors, Humans, Inhibitor of Apoptosis Proteins, Serpins, Viral Proteins