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Four mitochondrial proteins have been identified that immunoprecipitate with the mammalian inhibitor of apoptosis (IAP) protein XIAP. Each of them interacts via a processed amino terminus that resembles those of the insect pro-apoptotic IAP binding proteins Grim, HID, Reaper, and Sickle. Two, Diablo/Smac and HrtA2/Omi, have been extensively characterized. Both Diablo and HtrA2 can bind to IAPs and promote apoptosis when over-expressed in transfected cells, but unlike the insect IAP antagonists, to date there is scant evidence that they are important regulators of apoptosis in more physiological circumstances.

Type

Journal article

Journal

Biochem Biophys Res Commun

Publication Date

09/05/2003

Volume

304

Pages

499 - 504

Keywords

Animals, Apoptosis, Carrier Proteins, High-Temperature Requirement A Serine Peptidase 2, Inhibitor of Apoptosis Proteins, Intracellular Signaling Peptides and Proteins, Mammals, Mitochondrial Proteins, Models, Biological, Neoplasms, Proteins, Serine Endopeptidases, X-Linked Inhibitor of Apoptosis Protein