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'Programmed cell death' has been used to describe the death of cells killed by cytotoxic T cells or growth factor deprivation. Although bcl-2 can prevent death of cells deprived of growth factor, it failed to protect cells against T cell killing. In spite of bcl-2 expression, the DNA of targeted cells was degraded into nucleosome-sized fragments. Therefore the early steps in apoptosis induced by factor deprivation differ from those triggered by cytotoxic T cells, although they share a common final pathway featuring degradation of the DNA and loss of cytoplasmic membrane integrity.

Type

Journal article

Publication Date

07/1992

Volume

4

Pages

821 - 824

Keywords

Animals, Cell Death, Clone Cells, DNA, Gene Expression, Growth Substances, Humans, T-Lymphocytes, Cytotoxic