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Cell production within an organ is determined by the rate of immigration, proliferation, differentiation, emigration and death of cells. Abnormalities in any one of these processes will disturb normal control of cell production, thereby eliciting hyperplasia can be an early event in neoplasia. Cell death, apoptosis, is a physiological process responsible for removing unwanted cells. It is used in multi-cellular organisms for tissue remodelling during embryogenesis, regulation of cell turnover and as a defence strategy against invading pathogens. In this review article we describe the role of the bcl-2/ced-9 gene family in cancer and discuss the general implications of defects in the apoptosis program for tumourigenesis and resistance of cancer cells to chemotherapy in light of current knowledge of the molecular mechanisms of cell death.

Type

Journal article

Journal

Biochim Biophys Acta

Publication Date

24/10/1997

Volume

1333

Pages

F151 - F178

Keywords

Apoptosis, Apoptosis Regulatory Proteins, Caenorhabditis elegans Proteins, Cell Transformation, Neoplastic, Cyclin D1, Drug Resistance, Neoplasm, Genes, bcl-2, Genes, p53, Helminth Proteins, Humans, Mutation, Neoplasms, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2