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Programmed cell death is a physiological process that eliminates unwanted cells. The bcl-2 gene regulates programmed cell death in mammalian cells, but the way it functions is not known. Expression of the human bcl-2 gene in the nematode Caenorhabditis elegans reduced the number of programmed cell deaths, suggesting that the mechanism of programmed cell death controlled by bcl-2 in humans is the same as that in nematodes.

Type

Journal article

Journal

Science

Publication Date

18/12/1992

Volume

258

Pages

1955 - 1957

Keywords

Animals, Animals, Genetically Modified, Caenorhabditis elegans, Cell Death, Embryo, Nonmammalian, GTP-Binding Proteins, Gene Expression, Genotype, Humans, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2