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Gene deletion studies have helped reveal the unique and overlapping roles played by IAP proteins. Crossing IAP mutant mice has helped unravel the complex feed-back regulatory circuits in which cIAP1, cIAP2 and XIAP allow innate defensive responses to microbial pathogens, without the development of auto-inflammatory syndromes. Deletion of genes for Survivin and its homologs in yeasts, invertebrates and mammals has shown that it functions differently, as it is not a regulator of innate immunity or apoptosis, but acts together with INCENP, aurora kinase B and Borealin to allow chromosome segregation during mitosis.

Original publication

DOI

10.1016/j.semcdb.2014.12.004

Type

Journal article

Publication Date

03/2015

Volume

39

Pages

97 - 105

Keywords

BIR, Birc, Gene deletion, IAP, NAIP, Survivin, Animals, Chromosome Segregation, Feedback, Gene Deletion, Gene Knockout Techniques, Humans, Inhibitor of Apoptosis Proteins, Mice