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Background: The use of MDMA ('ecstasy') is common among young people in Western countries. Animal models of MDMA toxicity suggest a loss of serotonergic neurons, and potentially implicate it in the development of significant psychiatric morbidity in humans. Aims: To test whether long-term use of MDMA can produce abnormalities in cerebral serotonin, but not dopamine, transporter binding measured by single photon emission computed tomography (SPECT). Method: Ten male regular ecstasy users and 10 well- matched controls recruited from the same community sources participated in SPECT with the serotonin transporter (SERT) ligand [123I]β-CIT. Dopamine transporter binding was determined from scans acquired 23 hours after injection of the tracer. Results: Ecstasy users showed a cortical reduction of SERF binding, particularly prominent in primary sensory-motor cortex, with normal dopamine transporter binding in lenticular nuclei. Conclusions: This cross-sectional association study provides suggestive evidence for specific, at least temporary, serotonergic neurotoxicity of MDMA in humans. Declaration of interest: Funded by the Wellcome Trust and the Medical Research Council.

Type

Journal article

Journal

British Journal of Psychiatry

Publication Date

13/07/1999

Volume

175

Pages

63 - 69