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The 18F-labeling of 5-(trifluoromethyl)-dibenzothiophenium trifluoromethanesulfonate, commonly referred to as the Umemoto reagent, has been accomplished applying a halogen exchange 18F-fluorination with 18F-fluoride, followed by oxidative cyclization with Oxone and trifluoromethanesulfonic anhydride. This new 18F-reagent allows for the direct chemoselective 18F-labeling of unmodified peptides at the thiol cysteine residue.

Original publication

DOI

10.1021/jacs.7b10227

Type

Journal article

Journal

J Am Chem Soc

Publication Date

07/02/2018

Volume

140

Pages

1572 - 1575

Keywords

Fluorine Radioisotopes, Hydrocarbons, Fluorinated, Molecular Structure, Peptides