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Homeodomain and fork head domain proteins are thought to act as transcription factors by binding to specific DNA target sequences and interacting with other proteins. Here I describe a motif which is present in members of both groups of transcription factor and which has been shown to modulate their ability to activate transcription. The presence of this motif in both homeodomain and fork head proteins indicates they may control transcription by a similar molecular mechanism, perhaps by interacting with the same cofactors.

Type

Journal article

Journal

FEBS Lett

Publication Date

30/06/1997

Volume

410

Pages

124 - 125

Keywords

Amino Acid Sequence, Animals, Conserved Sequence, Evolution, Molecular, Forkhead Transcription Factors, Homeodomain Proteins, Molecular Sequence Data, Nuclear Proteins, Transcription Factors, Transcription, Genetic