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The cell division cycle is a complex process by which cells grow and divide into two viable daughter cells. So that mistakes are not made in this crucial replication process, cells stop at one or more "checkpoints" in the cycle to query their internal state and external conditions, before proceeding to the next stage of the cycle. In this paper we study some simple mathematical models of cell cycle arrest in G1 ("Start") and G2. Our models help to relate the molecular mechanisms of these checkpoints with physiological properties of the cell cycle.

Type

Journal article

Journal

Prog Cell Cycle Res

Publication Date

1995

Volume

1

Pages

1 - 8

Keywords

Animals Cell Cycle/*physiology Cell Division/physiology G1 Phase G2 Phase Mammals/physiology *Models, Biological Oocytes/cytology Saccharomyces cerevisiae/cytology Signal Transduction Xenopus laevis